酒精所致精神障碍患者事件诱发电位P300的研究  

Study of the event-related potentials P300 in patients with alcohol-induced mental disorders

作　　者：任方芳[1] 钱卫娟[1] 刘刚[1] 范俭雄[1] 

机构地区：[1]南京医科大学附属脑科医院,210029

出　　处：《临床精神医学杂志》2013年第6期376-378,共3页Journal of Clinical Psychiatry

基　　金：南京市医学科技发展项目(YKK10120)

摘　　要：目的:探讨酒精所致精神障碍患者事件诱发电位P300的特点。方法:对30例酒精所致精神障碍患者(研究组)和31名正常人(正常对照组)进行事件诱发电位P300的检测,并与正常对照组进行配对t检验和相关分析。结果:与正常对照组比较,酒精所致精神障碍患者P300潜伏期N2、P3显著延长(t=2.318,t=2.335;P<0.05);P300波幅N1、N2、P3显著降低(t=-2.414;t=-2.613,t=-4.453;P<0.05或P<0.001)。相关分析显示,酒精所致精神障碍患者饮酒年限以及饮酒量与P300潜伏期、波幅之间无明显相关(r=-0.128^-0.274,r=-0.075~0.328;P均>0.05)。结论:酒精所致精神障碍患者存在认知功能损害,P300可作为酒精所致精神障碍患者检测项目之一。Objective：The study is to explore the characteristic of event-related potentials [300 in pa- tients with alcohol-induced mental disorders. Method：Thirty patients with alcohol-induced mental disorders （study group） and thirty-one normal controls （control group） were examined with event-related potentials P300. The results were compared by paired-samples t test analysis and correlation analysis with control group. Results ： To compare with control group, the latency of N2,193 of patients with alcohol-induced mental disorders were significantly prolonged （ t = 2.318, t = 2. 335 ; P 〈 0.05 ） ; the wave amplitude of N1, N2, lY3 of alcohol-in- duced mental disorders were significantly lower （t = -2.414,t = - 2. 613,t = -4. 453 ;P 〈0. 05 or P 〈0. 001 ）. No correlation was found between the patients with alcohol induced mental disorders and length of drinking alcohol intake and P300 latency and amplitude（r = -0. 128- -0.274,r = -0. 075-0. 328;all P 〉0.05）. Conclusion：Pa- tients with alcohol-induced mental disorders show cognitive impairment,P300 can be used as one of the clinical examinations for patient with alcohol-induced mental disorder.

关 键 词：酒精所致精神障碍 事件诱发电位P300 认知损害 

分 类 号：R749.6[医药卫生—神经病学与精神病学]