胸腺肽α_1联合康艾注射液对肝细胞癌患者TACE术后细胞免疫功能的影响  

Effect of thymosin α_1 combined with Kangai injection on cellular immune function of patients with hepatocellular carcinoma after TACE

作　　者：刘凌云[1] 孟洁[1] 何沙[1] 吕一[1] 卢永刚[1] 

机构地区：[1]柳州市柳铁中心医院肝胆胰外科,广西柳州545007

出　　处：《海南医学》2013年第24期3605-3607,共3页Hainan Medical Journal

摘　　要：目的观察联合使用胸腺肽α1和康艾注射液对肝细胞癌患者经肝动脉化疗栓塞术(TACE)术后细胞免疫功能的影响。方法随机选取我科住院的肝细胞癌行TACE治疗患者51例,分为A、B两组,A组26例术后第1天开始联合使用胸腺肽α1及康艾注射液进行一个疗程治疗,B组25例除不使用胸腺肽α1外,其他治疗同A组,C组42例为健康体检者。分别在TACE术后第一天胸腺肽α1及康艾注射液治疗前、治疗后1个月应用流式细胞术检测其外周血T淋巴细胞亚群及NK细胞水平。结果肝细胞癌患者细胞免疫功能较正常人显著降低,A组治疗后外周血CD3+、CD4+、CD4+/CD8+比值及NK细胞均明显高于治疗前(P<0.05),而CD8+水平明显低于治疗前(P<0.05),B组治疗前后T淋巴细胞亚群及NK细胞无明显变化(P>0.05)。结论联合使用胸腺肽α1与康艾注射液可提高肝细胞癌患者TACE术后细胞免疫功能。Objective To investigate the effect of thymosin ctl combined with Kangai injection on cellular immune function of patients with hepatocellular carcinoma after TACE. Methods Fifty-one patients with hepatocel- lular carcinoma treated by TACE were randomly divided into group A and group B. Patients in group A （n=26） were treated by thymosin ct~ combined with Kangai injection from the first day after TACE for one course of treatment, while those in group B （n=25） were only treated by Kangai injection for one course of treatment. Forty-two healthy in- dividuals were selected as group C. Peripheral blood T lymphocyte subsets and NK cells were detected by flow cytom- etry in the first day （before thymosin ~, and Kangai injection） and one month after TACE treatment. Results The cel- lular immune function in patients with hepatocellular carcinoma were significantly lower than that in the healthy peo- ple. CD3~, CD,~, CD4YCDg~ ratio and NK cells were significantly higher than those before thymosin ct, and Kangai in- jection treatment in group A （all P〈0.05）, while CD,~ was significantly lower than that before thymosin ct~ and Kangai injection treatment （P〈0.05）. There was no statistically significant difference in T lymphocyte subsets and NK cells in group B before and after treatment （all P〉0.05）. Conclusion The combined use of thymosin a, and Kangai injection after TACE can improve cellular immune function of patients with hepatoeellular carcinoma.

关 键 词：胸腺肽Α1 康艾注射液 肝细胞癌 免疫功能 经肝动脉化疗栓塞术 

分 类 号：R735.7[医药卫生—肿瘤]