miRNA-转录因子-靶基因前馈环路:肿瘤与动脉粥样硬化调控新机制  

The feed-forward loops of miRNA-TF-target gene: a new mechanism regulated tumour and atherosclerosis

作　　者：何兴兰 林小龙[1] 王佐[1] 

机构地区：[1]南华大学心血管疾病研究所,动脉粥样硬化湖南省重点实验室,衡阳421001

出　　处：《生命的化学》2013年第6期621-626,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81070221)

摘　　要：miRNA是一类长约21～25 nt,进化上高度保守的单链非编码RNA。随着对miRNA研究逐渐深入,发现miRNA和转录因子(transcription factor,TF)可以同时调控同一基因,即转录因子又可通过影响miRNA间接的调控该基因表达,这种由miRNA、转录因子与靶基因三者组成的调控环路称为前馈环路(feed-forward loop,FFL)。miRNA-转录因子-靶基因形成的前馈环路在动脉粥样硬化与肿瘤发生发展过程中发挥了重要的调控作用,对这些疾病的机制和防治研究具有重要意义。miRNAs are highly conserved, endogenous non-coding small （21-25 nt） single strand RNA molecules. Researchers have found that miRNA mediate a new gene regulation network, in which a master transcription factor （TF） regulates a miRNA and then together regulate a set of target genes. This kind of special gene regulate circuit motif is named feed-forward loops （FFL） in which miRNA, TF and target genes are often highly coordinated. The feed-forward loops ofmiRNA-TF-target gene may play an important role in the occurrence and development process of atherosclerosis and tumour. And this coordinated transcriptional and miRNA-mediated regulation is very important to the pathogenesis, prevention and treatment of this kind of diseases.

关 键 词：MIRNA 转录因子 靶基因 前馈环路 

分 类 号：R730.2[医药卫生—肿瘤]