CD44与HA特异性结合在肿瘤靶向给药中的应用  

Application of the specific binding between CD44 and HA in tumor-targeted drug delivery system

作　　者：王明[1] 陈雷[1] 王朴[1] 

机构地区：[1]山东大学药学院药物化学研究所,济南250000

出　　处：《生命的化学》2013年第6期633-637,共5页Chemistry of Life

基　　金：国家自然科学基金项目(81172108);山东省自然科学基金项目(ZR2010BM040)

摘　　要：设计肿瘤靶向性抗癌药物一直是研究热点。因为CD44在许多肿瘤细胞表面过表达,所以基于CD44与其配体透明质酸(hyaluronic acid,HA)的相互作用设计肿瘤靶向药物成为一个新的研究方向。本文介绍了CD44的基本结构及CD44与HA之间的相互作用,并对以CD44为靶点的靶向抗癌药物研究进展进行了简介。Designing tumor-targeted drugs has always been a research hotspot. As CD44 is over-expressed in various tumor cells, the design of the tumor-targeted drug delivery system based on the specific binding between CD44 and HA has become a new research direction. This paper described the basic structure of CD44 and the interaction between CD44 and HA. Research progress in the design of anti-tumor drug delivery system that targets CD44 was also reviewed.

关 键 词：CD44 透明质酸 肿瘤靶向性给药系统 

分 类 号：R73-361[医药卫生—肿瘤]