细胞外ATP与肿瘤免疫  

Extracellular ATP and tumor immunity

作　　者：吴红艳[1] 王艳林[2] 

机构地区：[1]三峡大学医学院免疫教研室,宜昌443002 [2]三峡大学分子生物学研究所,宜昌443002

出　　处：《生命的化学》2013年第6期644-647,共4页Chemistry of Life

基　　金：国家自然科学基金项目(30973445);三峡大学人才启动基金(KJ2013B052)

摘　　要：ATP是最重要的胞内代谢产物之一,也是一种重要的信号分子。研究发现,某些凋亡刺激能诱导肿瘤细胞内ATP释放到细胞外,这种释放到细胞外的ATP能促进吞噬细胞对凋亡细胞的吞噬,由此激发特异性抗肿瘤免疫杀伤效应,提示细胞外ATP在肿瘤免疫治疗中的潜在应用价值。本文就细胞外ATP在肿瘤免疫中的研究进展作一综述。ATP is one of the most abundant intracellular metabolites and also an important messenger molecular. Recent researches have showed that some apoptotic stimulus can trigger release of intracellular ATP into extracellular matrix. The extracellular ATP could promote the engulfment of dying cells by antigen- presenting cells efficiently, and thus elicited specific anti-tumor immune response against homologous tumor cells, indicating the potential value of extracellular ATP in tumor immune therapy. Here, we summarize the research progress of extracellular ATP in tumor immunity.

关 键 词：细胞外ATP 免疫原性细胞死亡 肿瘤免疫 

分 类 号：R730.3[医药卫生—肿瘤]