BDNF-TrkB信号通路与焦虑障碍的产生  

Relationship between BDNF-TrkB signaling pathway and the generation of anxiety disorders

作　　者：林玉[1] 张瑞桐[1] 兰明[1] 张天娥[2] 闫智勇[1] 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]成都中医药大学基础医学院,成都611137

出　　处：《生命的化学》2013年第6期668-672,共5页Chemistry of Life

基　　金：国家科技重大专项"十一五"计划(2009ZX09103-370)

摘　　要：BDNF-TrkB信号通路对情绪产生、认知功能和记忆能力都有重要的影响,主要通过PI3-K途径和Ras-MAP激酶途径调节神经元的再生、凋亡及重建。近年来的研究表明,BDNF基因型及其表达量和TrkB受体表达的异常与焦虑障碍的产生有非常密切的关系。本文综述了近年来BDNF-TrkB信号通路及其与焦虑障碍产生的联系等方面的研究进展。BDNF-TrkB signaling pathway has important influence on emotion production, cognitive function and memory ability. BDNF regulates neuronal regeneration, apoptosis and reconstruction through PI3-K pathway and Ras-MAP kinase pathway. Recent studies have suggested that the genotype of BDNF and the abnormal expression of BDNF and TrkB have a very close relationship with the generation of anxiety disorders. In this paper, the relationship between BDNF-TrkB signaling pathway and the generation of anxiety disorders will be reviewed.

关 键 词：脑源性神经营养因子 酪氨酸激酶受体B 信号通路 焦虑障碍 

分 类 号：R749.7[医药卫生—神经病学与精神病学]