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机构地区:[1]新疆维吾尔自治区克拉玛依市中心医院血液肿瘤科,834000
出 处:《中国医药》2013年第12期1726-1727,共2页China Medicine
摘 要:目的观察口服替吉奥治疗老年晚期胃癌的疗效和不良反应。方法23例老年进展期胃癌患者,口服替吉奥胶囊,40~60mg/次,2次/d,连续服用4周,休息2周,6周为1个周期,2个周期后评价疗效和不良反应。结果23例中完全缓解0例,部分缓解8例(34.7%)、稳定9例(34.7%)、进展6例(26.1%),有效率(完全缓解+部分缓解)为34.7%,肿瘤控制率(完全缓解+部分缓解+稳定)为73.9%。主要不良反应为骨髓抑制,胃肠道反应,色素沉着等。结论替吉奥是治疗进展期胃癌安全、有效的药物,特别适宜于老年体弱的患者。Objective To evaluate the efficacy and toxicity of tegafur for elderly advanced gastric cancer. Methods Twenty-three elderly patients with advanced gastric cancer were treated with tegafur capsule 40-60 mg each time, two times perday. The evaluation of efficacy and toxicity were performed on all patients after 2 cycles. Results Of the 23 patients,there were 0( 0% ) complete remission(CR) ,8 (34.7%) partial remission( PR), 9 ( 34.7 % ) stable disease (SD) and 6 ( 26.1% ) progression disease (PD). The total response rate ( CR + PR) was 34.7%. The disease control rate ( CR + PR + SD ) was 73.9%. The major toxicities included myelo suppression, gastrointestinal reaction and cutaneous pigmentation. Conclusion Tegafur is safe and effective in the treatment of advanced gastric cancer, especially for old and frail patients.
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