丹红注射液对溃疡性结肠炎患者CD62p的影响  

Therapeutic effects of Danhong injection on CD62p in patients with ulcerative colitis

作　　者：马刚[1] 戴伟杰[1] 

机构地区：[1]南京医科大学附属淮安第一医院消化科

出　　处：《皖南医学院学报》2013年第6期471-473,共3页Journal of Wannan Medical College

摘　　要：目的:探讨丹红注射液干预治疗对溃疡性结肠炎患者CD62p的影响并观察疗效。方法:将147例活动期溃疡性结肠炎患者随机分成干预组(74例)和未干预组(73例),未干预组仅给予柳氮磺胺吡啶,干预组加用丹红注射液,两个疗程后观察其疗效,并通过流式细胞仪检测CD62p治疗前后变化。结果:干预组总有效率93.2%,明显高于未干预组82.2%,χ2=4.1769,P<0.05;干预组CD62p治疗后下降(7.9±1.4)%,未干预组CD62p治疗后下降(4.6±1.1)%,两组治疗前后差异有统计学意义,P<0.01,两组之间疗效差别有统计学意义,P<0.01。结论:在传统治疗基础上加用丹红注射液有助于进一步降低血小板活化状态,并提高疗效。Objective：To observe the clinical effects of Danhong injection （ Chinese Materia Medica standardized product extracted from Radix Salviae Miltiorrhizae and Flos Carthami tinctorii ） on patients with ulcera-tive colitis and the impact on CD62p.Methods：147 patients of active ul-cerative colitis were randomly assigned to intervention group （ n=74 ） and non-intervention group （ n =73 ） .The two groups were treated on sul-fasalazine basis,yet the intervention group were given additional Danhong injection.Therapeutic effects were assessed after two sessions of medica-tion,and flow cytometry was used to detect the level changes of CD62p before and after therapy.Results：The total effective rate was 93.2% and 82.2% for the intervention group and non-intervention group,respectively （χ2 =4.1769,P〈0.05）.Decreased CD62p level was（7.9 ±1.4）%for the intervention group and（4.6 ±1.1）% for the non-intervention group＆nbsp;after medication , which suggested statistical difference between the two groups before and after therapy（P〈0.01）.Conclusion： Danhong injec-tion may improve the therapeutic effects on basis of conventional medica-tion through facilitating the platelet activation in patients with active ul-cerative colitis.

关 键 词：结肠炎 溃疡性 丹红注射液 CD62P 治疗结果 

分 类 号：R574.62[医药卫生—消化系统]