Inactivated Sendai Virus Induces Apoptosis in Murine Melanoma Cells by IGF-1R Down-regulation  

作　　者：GAO Hui XU Xiao Shuang CHEN Ze Dong ZHANG Quan XU Xiang Ming 

机构地区：[1]College of Clinical Medicine of Yangzhou University [2]Comparative medicine Center, Yangzhou University [3]Suzhou polytechnic institute of agriculture

出　　处：《Biomedical and Environmental Sciences》2013年第12期998-1002,共5页生物医学与环境科学（英文版）

基　　金：supported by Natural Science Foundation of Jiangsu Province(BK2011049);Jiangsu"333"Projects in Jiangsu Province(BK201140032);Innovation Fund ofYangzhou University(2012CXJ085)

摘　　要：The mortality of cancer patients has considerably improved due to progress in surgery, chemotherapy and radiotherapy. However, some types of cancers, such as melanoma, remain refractory to conventional strategies. Although melanoma accounts for only 4% of all dermatological malignancies, it is responsible for 80% of mortalities from skin tumors[11. The reported survival rate of melanoma over 5 years is not yet encouraging due to its chemo-resistance and rapid metastasis. Therefore, it is necessary to develop new drugs with potent activity and weak side-effect against melanoma.The mortality of cancer patients has considerably improved due to progress in surgery, chemotherapy and radiotherapy. However, some types of cancers, such as melanoma, remain refractory to conventional strategies. Although melanoma accounts for only 4% of all dermatological malignancies, it is responsible for 80% of mortalities from skin tumors[11. The reported survival rate of melanoma over 5 years is not yet encouraging due to its chemo-resistance and rapid metastasis. Therefore, it is necessary to develop new drugs with potent activity and weak side-effect against melanoma.

关 键 词：IGF Inactivated Sendai Virus Induces Apoptosis in Murine Melanoma Cells by IGF-1R Down-regulation 

分 类 号：R739.5[医药卫生—肿瘤]