肺癌患者血清HE4表达临床意义的初步探讨  

Preliminary Study of the Clinical Significance of Serum Human Epididymis Protein 4 （HE4） in Patients with Lung Cancer

作　　者：孙炜[1] 田小平[1] 庄惠芹[1] 朱礼刚[1] 杨成喜[2] 张蕾[2] 

机构地区：[1]连云港市第一人民医院检验科,江苏连云港222002 [2]连云港市第一人民医院肿瘤化疗科,江苏连云港222002

出　　处：《现代检验医学杂志》2013年第6期50-51,54,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨人附睾蛋白4（HE4）在肺癌患者血清中表达的临床意义。方法选取连云港市第一人民医院2012年7月～2013年3月间住院的有明确病理诊断的肺癌患者222例，其中肺鳞癌63例、肺腺癌113例、小细胞肺癌46例。正常对照组为同期在该院体检的132例健康成人，在Cobase601电化学发光免疫检测系统上检测其血清HE4水平，分析患者与正常对照组间水平差异、不同病理类型间差异，比较男、女性患者问HE4异常率差异。结果男性正常对照组血清HE4水平为77．9士23．6pmol／L，显著高于女性正常对照组的64．8±16．9pmol／L（t=3．671，P=0．000）；男性患者中肺鳞癌、肺腺癌和小细胞肺癌组血清HE4水平分别为125．1±65．5pmol／L，172．8±151．1pmol／L和162．9±120．0pmol／L，显著高于正常对照组（x2=47．30，P=0．000）；女性患者中肺鳞癌、肺腺癌和小细胞肺癌组血清HE4水平分别为124．5±98．2pmol／L，221.1土433．2pmol／L和116．4士40．2pmol／L，显著高于正常对照组（x2=43．8，P=0．000），不同病理类型异常率间差异无统计学意义（P〉0．05）。结论HE4在肺癌的临床诊断中是有意义的标志物，在男女性问的表达水平有差异。Objective To evaluate the clinical significance of serum expression of Human Epididymis Protein 4 （HE4） in pa- tients with lung cancer. Methods The serum HE4 levels in 222 lung cancer patients with clear pathological diagnosis who were hospitalized in the First People＇s Hospital of Lianyungang between July 2012 and March 2013 （including 63 cases of adenocarcinoma,ll3 cases of squamous cell carcinoma, and 46 cases of small cell carcinoma） and 132 healthy adults who went through physical examinations at the hospital during the same period, were measured using electrochemiluminescence immunoassay （ECLIA） on Cobase 601 Immunoassay Analyzer and analyzed to compare the differences of serum HE4 levels in lung cancer patients and normal control group, the differences among different pathological cases, and the abnormal rate differences between male and female patients. Results The serum HE4 level of the male control group was 77.9 ± 23.6 pmol/L which was significantly higher than 64. 8± 16.9 pmol/L of the female control group （t= 3. 671, P= 0. 000）. The se- rum HE4 levels of male patients with lung squamous cell carcinoma, adenocarcinoma and small cell lung cancer were 125.1± 65.5 pmol/L, 172.8± 151.1 pmol/L and 162.9 ±120.0 pmol/L respectively, each significantly higher than that of the con- trol group （X2 = 47.30, P= 0. 000） ;the serum HE4 levels of female patients with lung squamous cell carcinoma, adenocarci- noma and small cell lung cancer were 124.5± 98.2 pmol/L, 221.1 ± 433.2 pmol/L and 116.4 ± 40.2 pmol/L respectively, each significantly higher than that of the control group （x2 = 43.8, P = 0. 000） ;however, there was no statistically significant difference between the abnormal rates among different pathological groups （P〈0.05）. Conclusion Serum HE4 is a mean- ingful tumor marker in clinical diagnosis of lung cancer and there were differences in the expression levels between male and female patients.

关 键 词：人附睾蛋白4 肺癌 肿瘤标志物 诊断 

分 类 号：R734.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]