脑恶性胶质瘤手术切除联合放化疗的对比分析  

A Contrastive study of gliomas treated with postoperative radiotherapy with or without chemotherapy

作　　者：张鹏 卢颖[2] 

机构地区：[1]郑州颐和医院神经外科,河南450047 [2]新乡医学院护理学院,河南453000

出　　处：《社区医学杂志》2013年第24期4-6,共3页Journal Of Community Medicine

摘　　要：目的回顾性分析脑恶性胶质瘤术后放化疗联合治疗临床疗效。方法选取2009年1月至2010年6月郑州颐和医院神经外科收治的胶质瘤患者92例，手术肉眼全切64例，部分切除28例。随机分为两组，A组采用手术切除后联合放化疗，B组手术切除后进行放疗。比较两组患者的近期、远期疗效以及不良反应发生率。结果A组患者的近期有效率（67．4％～71．7％）高于B组（41．3％～47．8％），A组术后1、2、3年生存率分别为82．6％、50．0％和32．6％，也高于B组，具有统计学差异（P〈0．05或P〈0．01）。两组患者的不良反应发生率无差异。结论脑恶性胶质瘤术后放化疗联合治疗有较好疗效，不良反应较少，值得临床推广。Objective To analyze the clinical efficacy of malignant glioma treated by combined chemotherapy and radio- therapy after surgery. Methods Ninety - two patients with glioma were selected who had received treatment in our hospi- tal from January 2009 to June 2010. Of them, 64 patients received grossly total reseetion, 28 patients subtotal resection and all cases were randomly divided into two groups. Group A received chemotherapy plus radiotherapy after resection, while group B underwent radiotherapy alone. Both groups were compared for short - term and long - term efficacy, and adverse reactions. Results The short - term effective rate of A group was 67.4% ~ 71.7%, which was higher than that of B group（41.3% ~47.8% ）. The 1 - , 2 - , and 3 - year survival rate of group A were 82.6%, 50.0% and 32.6% re- spectively, which were higher than those of group B. There was no significant difference in adverse reactions between the two groupsConelusions Combined chemotherapy and radiotherapy is effective for malignant glioma with less adverse re- actions, which is worthy of promotion.

关 键 词：脑肿瘤 放疗 化疗 恶性胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]