赛若金甲地孕酮配合EP方案与单纯EP方案治疗晚期非小细胞肺癌的对比研究  

Comparative Study of IFN α_(1b) and Megestrol Acetate Plus EP Regimen with EP Regimen Alone in the Treatment of Advanced Non-small Cell Lung Cancer

作　　者：谢忠[1] 潘达超[1] 廖思海[1] 王伟[2] 

机构地区：[1]广东医学院附属医院肿瘤中心,湛江市524001 [2]广东省农垦中心医院肿瘤内科,湛江市524001

出　　处：《中国药房》2000年第4期175-177,共3页China Pharmacy

摘　　要：目的 :比较IM -EP方案[即IFNα1b(赛若金 )、MA(megestrolacetate ,甲地孕酮 )、VP16 与PDD联合的生物化疗方案]与EP方案 (即VP16 加PDD的单纯化疗方案 )对初治Ⅲb～Ⅳ期非小细胞肺癌 (NSCLC)病人的疗效、毒性及生活质量的改善情况。方法 :A组 (33例 )接受IM -EP方案治疗 ;B组 (35例 )接受EP方案治疗。两组均以4wk为1周期 ,重复3个周期。客观疗效与毒性反应按WHO标准进行评价 ,生活质量根据临床受益疗效来评价。结果 :A、B两组客观疗效 (CR +PR)分别为27 3 %及22 9 % ,P>0 05 ;中位生存期A组32周 ,B组27周 (P<0 01) ;白细胞减少及恶心呕吐反应B组均较A组明显 (P<0 01) ;短暂性寒战、发热症状多见于A组 (P<0 01) ;两组均未发现其他严重的毒性反应。临床受益疗效A组高于B组 (P<0 05)。结论 :赛若金、甲地孕酮配合EP方案与单纯EP方案治疗晚期NSCLC的客观疗效无明显差异性 ,但前者毒副反应小 ,中位生存期长 。OBJECTIVE:To compare the effect,toxicity and quality of life(QOL) between IM-EP regimen and EP regimen alone in primary patients with advanced non-small cell lung cancer(NSCLC,stage Ⅲb～Ⅳ) METHODS:Group A(33 cases)were treated with IM-EP regimen and group B(35 cases)were treated with EP regimen Both regimens were repeated every 4 weeks for three cycles Objective tumor response and cytotoxic reactions were assessed by WHO criteria QOL was evaluated by clinical benefit response RESULTS:The objective response rate(CR+PR)was 27 3% in group A compared to 22 9% in group B(P>0 05) The median survival time was 32 weeks in group A compared to 27 weeks in group B(P<0 01) Leukopenia,nausea and vomiting in group B were more serious than those in group A(P<0 01),but transient fever and chill were much more common in group A(P<0 01) No other serious adverse reactions occurred in either group Clinical benefit response in gr_oup A was higher than that in group B(P<0 05) CONCLUSION:The present study indicated that IM-EP regimen had low_er toxicity,longer median survival time and better QOL than EP regimen alone for advanced NSCLC,however there was no significant statistical difference in the objective response rate between the two groups

关 键 词：干扰素Α1B 甲地孕酮 EP方案 非小细胞肺癌 治疗 

分 类 号：R734.205[医药卫生—肿瘤]