重症肌无力患者血清IgG-乙酰胆硷受体抗体亚型研究  

Study on the subclasses of IgG-AChR antibodies in serum in patients with myasthenia gravis

作　　者：李继民[1] 刘道宽[2] 吕传真[2] 蒋雨平[2] 肖保国[2] 乔健[2] 

机构地区：[1]南京医科大学附属脑科医院神经内科,210029 [2]上海医科大学华山医院神经病学研究所

出　　处：《临床神经病学杂志》2000年第5期263-265,共3页Journal of Clinical Neurology

摘　　要：目的 探讨重症肌无力（ＭＧ）患者血清ＩｇＧ－乙酰胆硷受体抗体（ＡＣｈＲＡｂ）亚型的分布规律及其临床意义。方法　采用ＡＢＣ－ＥＬＩＳＡ法检测４３例ＭＧ组和２５例临床对照组、２０例正常对照组血清中ＩｇＧ－ＡＣｈＲＡｂ亚型ＩｇＧ１－４。结果　ＭＧ组与两对照组相比ＩｇＧ１和ＩｇＧ４亚型抗体无显著差别，ＩｇＧ２亚型抗体显著升高（Ｐ＜０．０５），ＩｇＧ３亚型抗体显著降低（Ｐ＜０．０５）；ＭＧ组各临床类型间各亚型抗体无显著差别。结论ＩｇＣ－ＡＣｈＲＡｂ亚型以ＩｇＧ２活性为主，但未显示与ＭＧ临床类型有关。Objective To investigate the role and its clinical significance on the subclasses of IgG-AChR antibodies in serum in patients with myasthenia gravis. Methods ABCELISA technique was used to detect the subclasses IgG1-4 of IgG-AChR antibodies in sera from 43 patients with MG, 25 clinical controls and 20 normal controls. Results There was no obvious difference on IgG1 and IgG4 subclass antibodies between MG group and two control groups. IgG2 subclass antibodies increased significantly (P<0.05), IgG3 subclass antibodies decreased significantly(P＜0.05). There were no differences the various subclass antibodies among various clinical types in MG group. Conclusion IgG-AChR antibodies subclasses might take IgG2 activity as the dominant factor,but there was no any correlation with the clinical types of the disease.

关 键 词：重症肌无力 乙酰胆硷受体抗体 IGG亚型 

分 类 号：R746.1[医药卫生—神经病学与精神病学]