急性脑血管病患者血浆神经降压素的临床研究  

A clinical study on levels of neurotensin in plasma in patients with acute cerebrovascular disease

作　　者：李义召[1] 刘建伟[1] 张东君[1] 刘爱芬[1] 苏继新 谭东[1] 孙琳[2] 刘言训[3] 

机构地区：[1]山东医科大学附属医院,250012 [2]山东医科大学附属第二医院 [3]山东医科大学

出　　处：《临床神经病学杂志》2000年第5期278-281,共4页Journal of Clinical Neurology

摘　　要：目的 观察脑出血（ＣＨ）、脑梗死（ＣＩ）、蛛网膜下腔出血（ＳＡＨ）患者血浆神经降压素（ＮＴ）水平改变及其动态变化。方法 选择ＣＨ组４６例、ＣＩ组６２例、ＳＡＨ组３０例，用放免法检测血浆ＮＴ浓度。结果ＣＩ组、ＣＨ组、ＳＡＨ组ＮＴ水平均显著高于对照组，于发病后２４小时内显著升高，１～３天或４～７天达高峰，８～１５天开始下降，１５天后仍在较高水平；随病情加重与病灶扩大显著升高；ＣＩ与ＣＨ伴高血糖组均显著高于正常血糖组，ＣＨ伴高血压组、伴消化道出血组显著高于正常血压组与无消化道出血组。ＳＡＨ组伴ＤＩＤ组明显高于非ＤＩＤ组。结论 ＮＴ分泌异常参与了ＣＩ、ＣＨ、ＳＡＨ的病理生理过程。Objective To observe the level and dynamic change on neurotensin (NT) in plasma in patients with cerebral hemorrhage (CH),cerebral infarction (CI) and subarachnoid hemorrhage (SAH). Methods The concentration of NT in plasma was measured by radioimmunoassay in CH group for 46 cases, CI group for 62 cases and SAH group for 30 cases. Results The levels of NT in plasma in the three groups were significantly higher than that in control group. The levels of NT in plasma in the three groups started to increase significantly during 24 h after the onset. The levels of NT in plasma reached peak in the three groups from 1 to 3 days or 4 to 7 days,it began to decrease from & to 15 days,the levels of NT in the three groups were still higher 15 days later; the severer the patients' condition was, the higher the neurotensin level was;CI and CH groups with hyperglycemia were higher than the normal blood sugar group. CH group with hypertension, hemorrhage of digestive tract was higher than the normal blood pressure group and nonhemorrhage of digestive tract group. SAH group with DID was higher than non DID group. Conclusion The secretion abnormality of NT played a major role in pathophysiological course of CI, CH and SAH.

关 键 词：脑出血 脑梗死 蛛网膜下腔出血 神经降压素 

分 类 号：R743[医药卫生—神经病学与精神病学]