氮杂醇手性配体在锌催化的不对称Henry反应中的应用(英文)  

Application of Aziridino Alcohols as Chiral Ligands in Zinc-catalyzed Enantioselective Henry Reaction

作　　者：王晓娟[1] 李高伟[1] 王敏灿[2] 郭蕊[2] 刘澜涛[1] 赵文献[1] 

机构地区：[1]商丘师范学院化学化工学院有机新材料合成重点实验室,商丘476000 [2]郑州大学化学系,郑州450052

出　　处：《应用化学》2014年第1期33-40,共8页Chinese Journal of Applied Chemistry

基　　金：Supported by the National Natural Science Foundation of China(20972091,20972140)~~

摘　　要：以(S)-苯乙胺和丙烯酸甲酯为原料,方便地合成了一对非对映的氮杂醇手性配体,研究了它们在锌催化的不对称的Henry反应中不对称催化效果,β-硝醇的加成产物达到中等的催化效果(高达64%的ee值)。同时探讨了可能的催化机理。A pair of diastereoisomeric aziridino alcohols which could be readily prepared from the reaction between （S）-a-methylbenzyl amine and methyl acrylate has been used as chiral ligands in zinc-catalyzed enantioselective Henry reaction between nitromethane and arylaldehydes. A moderate enantioselectivity of β-nitroalcohol, up to 64% ee value, could be achieved in this catalytic reaction. The possible transition states of the reaction were proposed.

关 键 词：Henry反应 锌催化 氮杂醇配体 

分 类 号：O621[理学—有机化学]