肝动脉药盒灌注氟脲苷联合全身化疗治疗不可切除老年结直肠癌肝转移  

Hepatic Arterial Infusion with Floxuridine plus Systemic Chemotherapy for Elderly Patients with Unresectable Colorectal Cancer Liver Metastases

作　　者：王琦[1] 石亮荣[1] 赵洁敏[1] 周文杰[1] 胡文蔚[1] 单飞[1] 吴昌平[1] 

机构地区：[1]常州市第一人民医院肿瘤科,江苏常州213003

出　　处：《肿瘤基础与临床》2013年第6期484-487,共4页journal of basic and clinical oncology

基　　金：国家自然科学基金资助面上项目(编号:81171653;30972703);国家自然科学基金青年基金项目(编号:81201741;81301223);常州市卫生局资助项目(编号:WZ200824)

摘　　要：目的探讨经肝动脉药盒灌注(HAI)氟脲苷(FUDR)联合全身化疗治疗不可切除老年结直肠癌肝转移患者的疗效及安全性。方法对18例不可手术切除的老年结直肠癌肝转移回顾性分析。所有患者采用一种改进的介入方法植入肝动脉药盒,术后第2天开始接受HAI FUDR联合全身化疗。对治疗疗效、毒副反应及随访结果进行分析。结果 18例患者的总有效率为94.4%,其中完全缓解1例(5.6%),部分缓解16例(88.9%),疾病进展1例(5.6%)。8例患者转化为可手术切除,转化率为44.4%。中位无进展生存时间为26.0个月,中位总生存时间为30.2个月。结论 HAI FUDR联合全身化疗是治疗不可切除老年结直肠癌肝转移的一种安全有效的方法,可获得较高的手术切除率。Objective To evaluate the efficacy and safety of the hepatic arterial infusion （HAI）with floxuridine （FUDR） plus systemic chemotherapy in the treatment of elderly patients with unresectable colorectal cancer liver metastases. Methods HAI catheter systems were implanted by an innovative radiological method in 18 elderly pa- tients with unresectable colorectal cancer liver metastases. HAI FUDR and systemic chemotherapy were delivered in the next day after catheter implantation. The short-term effects, toxicities related to treatments and survival data were analyzed retrospectively. Results The overall response rate was 94.4% ,including 1 case （5.6%） of complete re- sponses, 16 cases （88.9%） of partial responses and 1 case （5.6%） of progressive disease. The median progressionfree survival and overall survival was 26.0 and 30.2 months respectively. Eight patients （44.4%） were converted to resectable. Conclusion HAI FUDR plus systemic chemotherapy is an effective strategy to obtain a high resection rate for elderly patients with unresectable colorectal cancer liver metastases.

关 键 词：结直肠癌 肝转移 肝动脉药盒灌注 

分 类 号：R735.3[医药卫生—肿瘤] R730.53[医药卫生—临床医学]