血清甲状腺球蛋白联合^(131)I全身显像在分化型甲状腺癌病情评估中的临床价值  

The clinical value of serum thyroglobulin combined with ^(131)I whole body scan in severity evaluation patients with differentiated thyroid cancer

作　　者：张然[1] 夏俊勇[1] 姚晓波[1] 罗玲玲[1] 刘学公[1] 

机构地区：[1]安徽医科大学附属省立医院核医学科,合肥230001

出　　处：《安徽医学》2013年第12期1829-1831,共3页Anhui Medical Journal

摘　　要：目的探讨甲状腺球蛋白(Tg)联合治疗剂量131I全身显像(131I-WBS)在已行131I清除残余甲状腺组织的分化型甲状腺癌(DTC)患者中监测肿瘤复发或转移的临床价值。方法 66例接受甲状腺全切或大部切除并已行131I清除残余甲状腺治疗的DTC患者,进行血清Tg测定和治疗剂量的131I全身显像。结果对DTC复发或转移灶诊断的灵敏度、特异度和准确性:Tg分别为78.7%、84.2%和80.3%;131I-WBS分别为85.1%、100.0%和89.4%;Tg联合131I-WBS分别为91.5%,84.2%和89.4%。结论血清Tg测定联合治疗剂量的131I全身显像在已行131I清除残余甲状腺治疗的DTC患者病情评估中有互补作用,对监测复发和转移病灶有重要的临床价值。Objective Tostudy the clinical value of serum thyroglobulin（Tg） combined with therapeutic dose 131I whole body scan （ 131I - WBS） in treating patients with differentiated thyroid cancer（ DTC ） as the monitor index of neoplasm recurrence or metastasis after 131I radiotherapy. Methods Sixty - six patients with DTC after radical or partial thyroidectomy and 131I radiotherapy were applied with serum Tg measurement and posttreatment 131I- WBS. Results Among 66 patients, the sensitivity of Tg and 131I - WBS in diagnosis of DTC recurrence or metastatic lesion was 78.7% and 85.1% , respectively, and the specificity was 84.2% and 85.1% , respectively; the accuracy was 80. 3% and 89.4%, respectively. The total sensitivity, total specificity and total accuracy of combination Tg with 131I - WBS was 91.5 %, 84. 2% and 89.4% , respectively. Conclusion Serum Tg measurement combined with therapeutic dose 131I - WBS in patients with DTC for monitoring recurrence and metastatic lesions has important clinical value.

关 键 词：分化型甲状腺癌 甲状腺球蛋白 131I全身显像 

分 类 号：R736.1[医药卫生—肿瘤]