阿托伐他汀对进展性脑卒中治疗作用的探讨  

Therapeutic effect of atorvastatin on stroke in progression

作　　者：季辉[1] 李俐涛[2] 温雅[1] 苗江永[1] 祝春华[1] 牛小芸[3] 张祥建[1] 

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000 [2]河北省人民医院神经内科 [3]北京嘉林药业股份有限公司

出　　处：《脑与神经疾病杂志》2013年第6期404-406,共3页Journal of Brain and Nervous Diseases

基　　金：国家自然基金项目(81371287)

摘　　要：目的探讨他汀类药物对进展性脑卒中的治疗作用。方法对发病在48 h内的105例进展性脑卒中患者临床资料进行研究。入选病例分为他汀治疗组及对照组:对照组47例采用常规治疗,未予阿托伐他汀治疗;他汀治疗组58例,在常规治疗基础上,每晚睡前口服阿托伐他汀钙20 mg·d-1。两组患者治疗前和治疗后14d采用NIHSS评分评价神经功能缺损情况。结果他汀治疗组NIHSS评分改善显著优于对照组(P<0.0 5)。结论他汀类药物可提高进展性脑卒中患者的疗效。Objective To investigate the effect of atorvastatin in stroke in progression （SIP）.Methods A retrospeetive cohorl study was conducted, involving 105 cases with SIP. Patients were divided into control and atorvastatin treatment groups. In atorvastatin group, patients were treated with 20 mg d-1 atorvastatin once a day for 14 days. Neurological deficit was determined using NIHSS at day 14.Results Neurological deficit was significantly improved in patients with atorvastatin treatment compared with the control group. Conclusion Atorvastatin is beneficial in improving the progression of ischemic stroke.

关 键 词：进展性脑卒中 阿托伐他汀 疗效 

分 类 号：R743.32[医药卫生—神经病学与精神病学]