不同部位脑出血患者肠黏膜屏障功能变化研究  

Study on intestinal mucosal barrier in patients with different cerebral hemorrhage

作　　者：王惠凌[1] 王强[1] 李烨[1] 王德超[1] 李震中[2] 

机构地区：[1]河北大学附属医院神经内科,保定071000 [2]河北医科大学第二医院神经内科

出　　处：《脑与神经疾病杂志》2013年第6期432-434,共3页Journal of Brain and Nervous Diseases

摘　　要：目的探讨不同部位脑出血(基底节区出血、脑干出血)患者肠黏膜屏障变化。方法选取脑出血患者共66例,其中脑干出血32例,基底节区出血34例,分别于患病后24h、72h、2w、4w采集静脉血,同时选取健康体检者30例作为对照,抽取外周血,采用双抗体夹心ELISA法测定血清二胺氧化酶(DAO)、D-乳酸(D-LAC)含量。结果无论基底节区出血还是脑干出血,患者在患病后很快出现肠黏膜屏障功能的改变,在患病24h达较高水平,随后的72h、1w及2w血清D-LAC及DAO持续高水平,两组患者于2w后呈降低趋势,两组在发病后4w明显降低,但仍高于对照组;结论不论基底节区出血还是脑干出血患者患病后24h内即可出现黏膜屏障功能损伤,两组患者肠黏膜屏障功能损伤可持续4w或更长时间。Objective To study the changes tff intestinal mucosal battier in patier, ts with different cerebral hemorrhage （hemisphere hemorrhage brain stem hemorrhag）. Methods 66 patients with cerebral hemmThage （34 was hemisphere hemorrhage and 32 was brain stem hemorrhag） , respectively in 24h, 72h,2w ,4w after the illness, venous blood was collected, and 30 healthy subjects served as control , The serum diamine oxidase （DAO） and D-lactic acid （D-LAC） were detected in 66 patients and 30 normal controls by double antibody enzyme linked immunosorbent assay .Results Whether hemispheric hemorrhage or brain stem hemorrhage, patients with intestinal mucosal barrier flmction changes soon after illness sickness, in 24 h 72 h, 1 week anti 2 weeks serum D-LAC and DAO levels remained high, lasted a higher level. The two groups patients showed decreasing trend after 2 w, and significantly decreased after 4 w, but still higher than that of the control group.Conclusion Hemisphere hemorrhage and brain stem hemorrhage patients can appear mucous membrane barrier function damage after illness in 24 h, and the damage can last 4 w or longer.

关 键 词：脑出血 肠黏膜通透性 肠黏膜屏障 

分 类 号：R743.34[医药卫生—神经病学与精神病学]