黛力新联合质子泵抑制剂治疗胃食管反流病伴咽喉部症状  

Effect of deanxit combined with proton pump inhibitor in treatment of gastroesophageal reflux disease with laryngopharyngeal symptoms patients

作　　者：王善娟[1] 张丽航[1] 刘艳丽[1] 毛峻岭[1] 

机构地区：[1]上海交通大学仁济医院嘉定分院消化内科,上海201800

出　　处：《胃肠病学和肝病学杂志》2013年第12期1192-1194,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的观察黛力新联合质子泵抑制剂(PPI)治疗胃食管反流病(GERD)咽喉部症状的临床疗效,探讨可能的治疗机制。方法选取2009年8月-2012年5月门诊确诊GERD,经PPI加促动力药治疗12周后仍有咽喉部症状的患者,用综合性医院焦虑抑郁量表(HADS)进行情绪评定,把其中HADS>9分患者分为两组,有症状黛力新治疗组,以黛力新+耐信+莫沙比利治疗;有症状对照组,以耐信+莫沙比利治疗;HADS<9分为无症状黛力新治疗组,以黛力新+耐信+莫沙比利治疗。疗程均为4周。三组治疗前后分别作Zung抑郁自评量表和Zung焦虑自评量表评分及临床疗效评分,观察其疗效。结果 HADS≥9分者63例,黛力新治疗组32例,对照组31例;HADS<9分者35例。有症状黛力新治疗组与无症状黛力新治疗组的疗效相比,差异无统计学意义(P>0.05),但高于有症状对照组,且差异有统计学意义(P<0.05),有症状黛力新治疗组治疗后SDS和SAS指数均明显下降(P<0.05)。结论黛力新联合PPI治疗伴有咽喉部症状的GERD能显著改善患者精神和躯体两方面的症状。Objective To assess the clinical effects of deanxit combined with proton pump inhibitor （PPI） in treat- ment of gastroesophageal reflux disease （GERD） and laryngopharyngeal symptoms, and discuss the possible therapeutic mechanism. Methods Outpatients with GERD from Aug. 2009 to May. 2012 who had the laryngopharyngeal symptoms after treatment with 12 weeks PPI and prokinetic drugs were collected. The scores of comprehensive hospital anxiety and depression scale （HADS） were evaluated, patients who the score of HADSt〉9 were divided into two groups, Symptom- atic treatment group was treated with deanxit plus esomeprazole and mosapride citrate, symptomatic control group was treated with esomeprazole and mosapride citrate. Patients whose score of HADS 〈 9 were also treated with deanxit plus esomeprazole and mosapride citrate as a sympto-matic treatment group for four weeks. The efficacy of three groups by Zung Self-rating Depression Scale and Zung Self-rating Anxiety Scale score before and after treatment were observed. Results There were 63 patients whose HADS ≥9, 32 patients were treated with deanxit plus esomeprazole and mosa- pride citrate, 31 patients were treated with esomeprazole and mosapride citrate, and there were 35 patients whose HADS 〈 9. The curative effect of symptomatic treatment group was significantly higher than that of symptomatic control group, but there was no difference in curative effect between symptomatic treatment group and a symptomatic treatment group. Scores of SDS and SAS were decreased significantly after deanxit treatment in symptomatic treatment group. Conclusion Deanxit combined PPI may significantly improve the psychiatric and somatic symptom of GERD patients who had la- ryngopharyngeal symptoms.

关 键 词：胃食管反流病 咽喉部症状 黛力新 质子泵抑制剂 抗焦虑 

分 类 号：R571[医药卫生—消化系统]