度洛西汀治疗老年期抑郁障碍患者的对照研究  

Comparative study of duloxetine in treatment of elder patients with depression

作　　者：陈海波[1] 吴文艳[1] 李多聪[1] 陈海峰[1] 

机构地区：[1]江西省吉安市第三人民医院,江西吉安343000

出　　处：《中国民康医学》2013年第23期4-5,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:比较度洛西汀与舍曲林治疗老年期抑郁障碍的疗效。方法:将60例老年期抑郁障碍患者随机分为两组,分别采用度洛西汀和舍曲林治疗8周,采用汉密尔顿抑郁量表(MAMD)、汉密尔顿焦虑量表(HAMA)评定疗效及药物副反应量表(TESS)评定药物不良反应。结果:治疗后两组HAMD、HAMA量表总分与治疗前比较,差异均具有统计学意义(P<0.05)。度洛西汀组在第1、2周末的有效率及HAMD、HAMA减分幅度明显高于舍曲林组,差异具有统计学意义(P<0.05)。两组不良反应比较差异无统计学意义。结论:度洛西汀治疗老年期抑郁症患者是安全、有效的,起效更早,有利于患者康复。Objective：To compare curative effects of duloxetine and sertraline in treatment of elder patients with depression. Methods：60 elder patients with depression were randomized into duloxetine group and sertraline group. The treatment lasted for 8 weeks. Hamilton depression scale （MAMD） and Hamilton anxiety scale （HAMA） were used to evaluate the curative effects and treat- ment emergent symptoms scale （TESS） was applied to evaluate the adverse reactions. Results： The HAMD and HAMA scores of the two groups decreased significantly compared with those before the treatment （P〈0.05）. 1 and 2 weeks after the treatment, the effec- tive effects and the decrease of HAMD and HAMA scores of duloxetine group were significantly higher than those of sertraline group, and the difference was significant （P〈0.05）. The two groups showed no statistical difference in the adverse reactions. Conclusions： Duloxetine is safe and effective in the treatment of elder patients with depression, may act earlier, and is helpful for patients＂ rehabilita- tion.

关 键 词：度洛西汀 舍曲林 老年期抑郁障碍 

分 类 号：R749.42[医药卫生—神经病学与精神病学]