脑血液循环障碍患者急性期血清缺血修饰白蛋白的变化研究  

Changes of Ischemia Modified Albumin in Cerebral Circulation Disorder Patients

作　　者：蹇国 贾萍[1] 

机构地区：[1]广元市中心医院检验科,四川广元628000

出　　处：《标记免疫分析与临床》2013年第6期374-377,共4页Labeled Immunoassays and Clinical Medicine

基　　金：国家高技术研究发展计划(863计划)(2011AA02A111)

摘　　要：目的探讨检测缺血修饰白蛋白(IMA)对脑血液循环障碍患者早期诊断的价值。方法选择脑外伤患者29例,高血压性血管病患者37例,脑梗死患者41例,动脉硬化性脑血管病患者36例,非血管性因素患者21例。所有患者在起病3h内、6 h、48 h、72h检测血IMA水平。另选取30例健康体检者作为对照组。结果高血压性血管病组、脑梗死组、动脉硬化性脑血管病组血清IMA水平高于对照组(P<0.01);脑外伤组和非血管性因素组血清IMA水平高于对照组(P<0.05);高血压性血管病、脑梗死、动脉硬化性脑血管病组血清IMA水平高于脑外伤组和非血管性因素组(P<0.05);区分患病组和对照组的最适临界点为:120.32U/mL,此时敏感性为90.22%,特异性为70.21%;脑梗死组血清IMA值在72h内有上升趋势(P<0.05)。结论 IMA是反映脑血液循环障碍患者早期情况较敏感的指标,可用于早期诊断。Objective To explore the value of serum ischemia modified albumin （IMA） in the early diagnosis of cerebral circulation disorder. Methods The patients with cerebral trauma （n = 29） , hypertensive vascular dis- ease （ n = 37）, cerebral infarction （ n = 41 ） , arteriosclerotic cerebral vascular disease （ n = 36） and cerebritis （n = 21 ） were involved in this study. The IMA levels of all patients were detected within 3 hours of onset and 6, 48, 72 hours. Results The serum levels of IMA in hypertensive vascular disease, cerebral infarction, arte- riosclerotic cerebral vascular disease were significantly higher than those of healthy control （ P 〈 0.01 ） , the IMA levels in cerebral trauma and cerebritis were also higher than that in healthy control （ P 〈 0.05 ） , while the levels of IMA in hypertensive vascular disease, cerebral infarction and arteriosclerotic cerebral vascular were significantly higher than those in cerebral trauma and cerebritis （ P 〈 0.05 ）. The optimal cutoff value of IMA was 120.32U/mL in diagnosis of cerebral circulation disorder. At this point, its sensitivity and specificity were 90.22% and 70.21%. The levels of serum IMA at 3-72h in cerebral infarction would be upward trend. Con- clusion IMA might be used as a biochemical index in early diagnosis of cerebral circulation disorder.

关 键 词：缺血修饰白蛋白 脑血液循环障碍 诊断 

分 类 号：R743.3[医药卫生—神经病学与精神病学]