血清SCC、NSE、CYFRA21-1及CEA联合检测在肺癌诊断中的价值  

Diagnostic Value of Combined Detection of Serum Levels of SCC,NSE, CYFRA21-1 and CEA in Patients with Lung Cancer

作　　者：王会芳[1] 朱丽莉[1] 

机构地区：[1]涿州市医院检验科,河北涿州072750

出　　处：《标记免疫分析与临床》2013年第6期404-406,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨血清SCC、NSE、CYFRA21-1及CEA联合检测在肺癌的诊断价值。方法采用电化学发光免疫分析法测定血清SCC、NSE、CYFRA21-1及CEA水平及其组合,评价其在肺癌诊断中的价值。结果肺癌组四项指标显著高于对照组和肺良性疾病组,差异有统计学意义(P<0.05);不同病理类型的肺癌四项检测指标,差异有统计学意义(P<0.05);但四项指标联合检测敏感性明显高于任一个单项肿瘤标志物。结论单项肿瘤标志物对肿瘤的诊断价值有限。四项标志物联合检测有利于肺癌的早期诊断。Objective To explore the values of combined detection of serum levels of NSE, SCC, CYFRA21-1 and CEA in the diagnosis of lung cancer. Methods The serum levels of SCC, NSE, CYFRA21-1 and CEA in patients with lung cancer were detected by electrochemical luminescence assay. Results The serum levels of NSE, SCC, CYFRA21-1 and CEA in lung cancer group were significantly higher than those in control group and in lung benign disease group （ P 〈 0.05 ）. There were significantly differences on the serum levels of four markers between different pathological types of lung cancer（P 〈 0.05）. The detection sensitivity of combined detection of four markers was obviously higher than that of any single tumor marker. Conclusion The combined detection of serum levels of NSE, SCC, CYFRA21-1 and CEA would be helpful in the early diagnosis of lung cancer.

关 键 词：肺癌 鳞状细胞癌抗原 神经元特异性烯醇化酶 细胞角质素片段19 癌胚抗原 肿瘤标志物 电化学发光免疫分析法 

分 类 号：R734.2[医药卫生—肿瘤]