盐酸氟哌噻吨合成工艺研究  

Research on the Synthesis Process of Flupenthixol Dihydrochloride

作　　者：张立颖[1] 刘旭亮[2] 

机构地区：[1]山东理工大学,山东淄博255049 [2]山东新华制药股份有限公司,山东淄博255086

出　　处：《广州化工》2013年第24期64-65,共2页GuangZhou Chemical Industry

摘　　要：对盐酸氟哌噻吨合成工艺进行了优化研究。以2-三氟甲基-9-噻吨酮为起始原料,与1-(2-苄氧乙基)-4-(3-氯丙基)哌嗪进行格式反应,经脱水生成10-[3-[4-(2-苄氧乙基)-1-哌嗪基]丙基-9-羟基-2-三氟甲基噻吨,然后脱保护反应得氟哌噻吨游离碱,成盐而得盐酸氟哌噻吨成品,容量分析法检测纯度高于99.4%,收率大于59.0%。The synthetic process of flupenthixol dihydrochloride was studied. With 2 - trifluoromethylthioxanthen - 9 - one as starting material through Grignard reaction, dehydrationg was prepared, which was subject to salt formation. The average yield of flupenthixol dihydrochloride was more than 59.0% with a purity of 99. 4%.

关 键 词：盐酸氟哌噻吨 2-三氟甲基-9-噻吨酮 合成 抗精神病药 

分 类 号：R971.4[医药卫生—药品]