高度鳞状上皮内病变患者宫颈细胞学检测结果及其人乳头状瘤病毒基因高危亚型分析  

The results of cervical cytology of patients with HSIL and analysis of gene subtypes of high-risk human papilloma virus

作　　者：顾金云[1] 徐艺[1] 

机构地区：[1]江苏省连云港市东方医院妇产科,连云港222042

出　　处：《中国肿瘤临床与康复》2013年第12期1336-1338,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的分析高度鳞状上皮内病变(HSIL)患者人乳头状瘤病毒(HPV)感染亚型的分布特点,探讨HPV分型检测在宫颈高度病变筛查中的作用。方法对137例患者进行HPV分型检测,并对HPV基因高危亚型进行分析,分析HPV亚型的检出情况,并比较HPV分型与病理结果。结果 31～40岁组和41～50岁组的阳性率分别为92.2%和89.6%,均高于≤30岁组(73.3%)和≥51岁组(82.6%,P<0.05);单型感染者62例,多重感染者58例,差异无统计学意义(P>0.05)。HPV各类型中,以16及58型感染为多,其次是52、33和18型。单型感染和多重感染均主要以16、58和52型感染为主。高危型阳性的检出率为3.3%(4/120),高于高危型阴性中宫颈癌的检出率(0,P<0.05);高危型阳性炎症、疣症及疣、CINⅠ、CINⅡ和CINⅢ的检出率分别为25.0%(30/120)、28.3%(34/120)、25.0%(30/120)和18.3%(22/120),均高于高危型阴性的检出率(P<0.05)。结论高危型HPV感染以16和58型感染为多,在宫颈病变进行高危型HPV检测对宫颈病变诊治和癌变预防起到指导性的作用。Objective To investigate human papilloma virus（ HPV） infection subtypes distribution characteristics of the high grade squamous intraepithelial lesion（ HSIL） patients,and to study the role of HPV subtype detection in the screening of cervical high grade lesion. Methods HPV genotyping of 137 patients were detected and high-risk subtypes were analyzed. HPV typing and pathological results were compared. Results The positive rates of 31-40 and 41-50 year-old group were 92. 2% and 89. 6%,which were higher than ≤30（ 73. 3%） and ≥51 year-old group（ 82. 6%,P〈0. 05）. 62 case suffered from single type infection and 58 cases from multiple infection,no significant difference was observed（ P〈0. 05）. Among them,16 and 58 type infection owned most,52,33 and 18 were less comparatively. Single infection and multiple infections were mainly 16,58,52 type. High-risk positive rate of 3. 3%（ 4 /120） was higher than that of negative cervical cancer detection rate（ P〈0. 05）. In high-risk positive inflammation,wart disease and warts, CINⅠ,CINⅡand CIN Ⅲ accounted for 25. 0%（ 30 /120） 、28. 3%（ 34 /120） 、25. 0%（ 30 /120） and 18. 3%（ 22/120） respectively,which were higher than those of high-risk negative（ P〈0. 05）. Conclusions The main high-risk HPV infection were16 and 58 type. The high-risk HPV detection in cervical lesions could make referrence for the diagnosis and treatment of cervical diseases and cancer prevention.

关 键 词：宫颈上皮内瘤变 人乳头状瘤病毒 高危亚型 

分 类 号：R737.33[医药卫生—肿瘤]