血清HS-CRP、PCT含量与脑卒中患者疾病的关系  

Relationship between disease of stroke patients and levels of serum HS- CRP and PCT

作　　者：吴东川[1] 尹石华[2] 王广君[1] 吴晓霞[1] 寇忠爱[1] 徐英[1] 韩来新[2] 孙征[2] 

机构地区：[1]胜利石油管理局胜利医院神经内科,山东东营257055 [2]胜利石油管理局胜利医院检验科,山东东营257055

出　　处：《实用临床医药杂志》2013年第24期27-30,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨高灵敏C-反应蛋白（HS-CRP）、降钙素原（PcT）在脑卒中疾病治疗中的应用价值。方法选取本院2012年3月至2013年1月首次发病在神经内科脑卒中住院患者97例为研究组，其中连续发热48～72h有80例，对其再次取血进行血清HS-CRP、PcT含量测定，以体温38．5℃为界，分为高体温组29例，低体温组51例；48例中老年健康体检人员作为对照组，检测血清中HS＇-CRP与PCT含量，并根据临床资料和统计分析，评价其与脑卒中的疗效关系。结果研究组患者血清Hs_CRP、PCT含量显著高于对照组（P〈0．001），高体温组Hs-CRP、PCT含量显著高于低体温组和体温正常组（P〈0．01），HS—CRP在高体温组和低体温组中的阳性率基本相同，和细菌阳性率在高体温组及低体温组差异有统计学意义（P〈0．001），PCT含量升高在诊断细菌性感染方面优于Hs-CRP。结论根据血清HS-CRP、PCT含量测定可指导脑卒中患者高热时抗生素治疗的选择，以减少抗生素的使用及其耐药性。Objective To explore the value of high sensitivity c- reactive protein and pro- calcitonin in the treatment of patients with stroke. Methods 97 hospitalized patients with stroke collected from March 2012 to January 2013 were designed as research group, and 80 of them had persistent fever for 48 to 72 hours. 80 patients were divided into high temperature group （ n = 29） and low temperature group （n = 51） according to standard temperature of 38.5 ℃. 48 middle and old aged healthy people were collected and designed as control group. Levels of serum HS - CRP and PCT were detected, and relationship between the efficacy and levels of serum HS- CRP and PCT were evaluated. Results Levels of serum HS- CRP and PCT in the research group were signifi- cantly higher than those in the control group（P（0.01 - 0. 001）, and levels of HS- CRP and PCT in the high temperature group were significantly higher than those in the low temperature group and the control group （P（0.01 -0. 001）. Positive rates of HS-CRP in the high temperature group and the low temperature group were nearly the same, and there were significant differences of posi tive rates of PCT and bacteria in the high temperature group and low temperature group （P （0. 001 ）. Value of PCT level was significantly greater than the HS - CRP level in the diagnosis of bac terial infection. Conclusion Detection of serum HS- CRP and PCT can be used for the antibiotics choice in stroke patients with high fever, and it can reduce the use of antibiotics and resistance.

关 键 词：高灵敏C反应蛋白 降钙素原 脑卒中 脑出血 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]