食管癌术后早期持续滴注羟乙基淀粉对组织水肿的影响  

Influence of early postoperative continuous drip of hydroxyethyl starch on treatment of tissue edema in patients with esophageal cancer surgery

作　　者：袁欣[1] 王雁冰[1] 陈晓峰[1] 陈艾江 黄志斌 张江涛 赵娜[1] 

机构地区：[1]河北省保定市第二中心医院胸外科,河北保定072750 [2]河北省张北县卫生局医政股,河北张北076450

出　　处：《实用临床医药杂志》2013年第24期48-50,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321244)

摘　　要：目的评价食管癌术后早期持续滴注羟乙基淀粉对组织水肿的影响。方法胸段食管鳞癌患者100例随机分为3组:观察组50例,采用术后早期持续滴注羟乙基淀粉;对照组A 31例,采用术后间断滴注羟乙基淀粉;对照组B 19例,术后不用羟乙基淀粉。术前、术后不同时相应用超声测量胫骨前皮下组织厚度,计算皮下组织增厚值,分类比较。结果观察组在1、3、5 d皮下组织增厚均低于对照组,两两比较在1、3、5 d皮下组织增厚观察组分别低于两对照组。对照组A在1、3、5 d低于对照组B。术后7 d,各组水肿情况无统计学差别。各组在手术后不同时相均出现相似的水肿变化规律。结论食管癌术后早期滴注羟乙基淀粉可以减轻术后组织水肿,持续滴注的方法使其作用效率更高。Objective To evaluate the influence of early postoperative continuous drip of hy droxyethyl starch on the treatment of tissue edema in patients with esophageal cancer surgery. Meth ods 100 patients with esophageal squamous carcinoma in the thoracic segment were randomly di vided into three groups. Observation group （ n = 50） was continuously dripped with hydroxyethyl starch in early postoperative period, control group A （n = 31） was intermittently dripped with hy droxyethyl starch after operation, and control group B （n = 19） was not treated with hydroxyethyl starch. The subcutaneous tissue depth in the anterior tibia was measured by ultrasound at different phases before and after treatment, and its increased thickness was calculated and compared by classi fication. Results The increased thickness of subcutaneous tissue at the time points of 1, 3 and 5 days in the observation group were smaller than that in the control group A and the control group B, and the same index at the time point of 1, 3 and 5 days in the control group A was smaller than that in the control group B. 7 days after operation, there were no significant difference of edema among three groups. Similar changing rules of edema were appeared in different phases after operation in the three groups. Conclusion Early postoperative continuous drip of hydroxyethyl starch in patients with esophageal cancer surgery can alleviate postoperative tissue edema, and continuous drip method can improve therapeutic efficacy.

关 键 词：食管癌 围术期 目标容量导向治疗 组织水肿 

分 类 号：R735.1[医药卫生—肿瘤]