紫草素诱导消化系统肿瘤细胞凋亡的研究进展  

Research Progresses of Shikonin Inducing Apoptosis in Digestive System Neoplasms

作　　者：郭雪兴 陈剑群[2] 

机构地区：[1]徐州医学院,江苏徐州221002 [2]徐州医学院附属医院消化内科,江苏徐州221002

出　　处：《医学综述》2013年第24期4450-4452,共3页Medical Recapitulate

摘　　要：紫草素是从中药紫草中提取的萘醌类化和物,具有抗炎、抗氧化、抗血小板、抗肿瘤等多种药理活性。紫草素能明显抑制肝癌、结肠癌、胃癌细胞的增殖并诱导其凋亡,而对正常细胞不良反应小,其作用机制包括激活胱天蛋白酶家族启动凋亡、引起Bcl-2蛋白酶家族表达变化从而促进细胞色素C的释放、诱导活性氧类的产生等。该文对紫草素诱导消化系统肿瘤细胞凋亡的作用及其机制进行综述。The naphthoquinone pigment,shikonin,isolated from lithospermum erythrorhizon,has multiple pharmacological properties such as anti-inflammatory,antioxidant,antiplatelet and antitumor effects etc. Shikonin can inhibit cell proliferation in hepatic cancer,colon cancer or gastric cancer and induce apoptosis of such cancers,while it has less cytotoxic side-effect on normal cells,through the mechanisms including： activating caspase protease family to initiate apoptosis,causing changes in expression of Bcl-2 family of proteinsto promote the release of cytochrome C and induce the production of reactive oxygen species. Here is to make a review of the apoptosis-inducing effects of shikonin on digestive system neoplasms and its mechanisms.

关 键 词：紫草素 肝癌细胞 结肠癌细胞 胃癌细胞 

分 类 号：R57[医药卫生—消化系统]