炎症反应在NAFLD发病中的作用研究进展  

Inflammation and nonalcoholic fatty liver disease

作　　者：柏云[1] 刘志国[1] 

机构地区：[1]武汉工业学院生物与制药工程学院,湖北武汉430023

出　　处：《武汉工业学院学报》2013年第4期98-102,共5页Journal of Wuhan Polytechnic University

摘　　要：非酒精性脂肪性肝病(NAFLD)是临床上最为常见的的肝病之一,炎症反应贯穿了NAFLD整个病变过程,其发病机制尚未完全阐明。目前认为胰岛素抵抗(IR)、氧化应激以及内质网应激(ERS)在NAFLD发病中起着重要作用。就炎症反应通过参与IR、氧化应激和ERS影响NAFLD进展作一综述。Nonalcoholic fatty liver disease（ NAFLD） is one of the most common clinical liver disease,and its path- ogenesis has not yet been fully elucidated. It is believed that insulin resistance（ IR）,oxidative stress and endo- plasmic reticulum stress（ ERS） plays an important role in the progress of NAFLD. Yet,inflammation throughout the whole progression of NAFLD,so,inflammatory response affects NAFLD through IR,oxidative stress and ERS is reviewed.

关 键 词：NAFLD 炎症 胰岛素抵抗 氧化应激 内质网应激 

分 类 号：R575.1[医药卫生—消化系统]