放射性肺损伤预测因子与治疗进展  

Progress of predictors and treatment for radiation - induced lung injury

作　　者：吕达(综述)[1] 乔文波(审校)[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院放射治疗科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2013年第6期554-558,共5页Practical Oncology Journal

基　　金：1.黑龙江省教育厅科学技术研究项目（11531194）;2.黑龙江省自然科学基金项目（D200913）

摘　　要：胸部肿瘤治疗过程中大约2／3的患者需要放射治疗，治疗期间正常肺组织不可避免接受一定量的放射线照射，由此导致胸部肿瘤放疗中最常出现的并发症：放射性肺损伤（Radiation—inducedlunginjury，RILI），通常放射学改变比临床表现更为常见。Rlu已成为制约提高肿瘤放疗疗效的瓶颈。目前尚无准确可靠的方法能够预测RILl的发生，RILl一旦发生后病情不可逆转，治疗手段近几十年来也一直处于停滞阶段，下面将现在已知的RII。I预测因子与治疗手段及未来新的研究思路做一综述。About 2/3 patients with chest tumor requires radiation therapy. Normal lung tissues inevitably receive a certain amount of radiation during the treatment,which results in the most frequent complication in tho- racic tumor radiotherapy ： radiation - induced lung injury （ radiation - induced lung injury, RILl ）. Usually, radio- logical changes are more common than clinical manifestations. RILI has become the bottleneck in radiotherapy which restricts the improvement of efficacy. At present, there is no accurate and reliable method to predict the oc- currence of RILl. Once RILI occurs,the condition is irreversible and treatment in recent decades has been stag- nant. In the present review, we summarized the RILI predictors and RILl treatment methods.

关 键 词：放射性肺损伤 细胞因子 基因多态性 基质金属蛋白酶 治疗 

分 类 号：R734.2[医药卫生—肿瘤]