浊度计法测定注射用磷霉素钠溶液的澄清度  

A Study of Checking Clarity of Fosfomycin Sodium for Injection

作　　者：陈国旗[1] 刘杨[1] 姜雯[1] 

机构地区：[1]辽宁省食品药品检验所,辽宁沈阳110023

出　　处：《中国医药指南》2013年第35期311-312,共2页Guide of China Medicine

摘　　要：目的建立浊度计测定注射用磷霉素钠溶液澄清度的方法。方法应用浊度计测定溶液澄清度,溶液澄清度与浊度计测定值呈良好的线性,R2=0.9902;测定结果重复性较好,RSD为1.5%(n=6)。结果采用目视比浊法及浊度计法对三个生产企业3个规格共140批样品进行对比测定,二者结果一致。结论采用浊度计测定注射用磷霉素钠溶液澄清度,方法简便、准确,可消除人为误差,方法可行。Objective to check clarity of fosfomycin sodium for injection. Method visible turbidimetric method and turbidimeter method was applied for contrasting testing of 140 batch samples from Three production enterprise. Results The Main influencing factor of clarity of fosfomycin sodium for injection is the stopper quality. Conclusion The use of coating stopper is sometimes proposed to improve the clarity of drug.

关 键 词：注射用磷霉素钠 溶液澄清度 浊度计 

分 类 号：R914[医药卫生—药物化学]