GP73与AFP在原发性肝癌诊断中的意义  

Significance of Golgi protein 73 and Alpha-fetoprotein on the diagnosis of primary hepatic carcinoma

作　　者：郭婧婧[1] 肖成锋[2] 钟白云[1] 冯斯斯[1] 张秋焕[1] 谢婷彦[1] 邓辉[1] 

机构地区：[1]中南大学湘雅医院检验科,湖南长沙410008 [2]湖南师范大学医学院检验系,湖南长沙410013

出　　处：《中国现代医学杂志》2013年第31期35-37,共3页China Journal of Modern Medicine

基　　金：湖南省自然科学基金(No:12JJ3089)

摘　　要：目的探讨高尔基体蛋白73(GP73)及甲胎蛋白(AFP)单项指标检测与联合检测在原发性肝癌诊断中的意义。方法收集129例血清,其中原发性肝癌(PHC)44例、肝硬化19例、慢性肝炎44例、健康对照22例,分别用酶联免疫吸附试验检测血清GP73,电化学发光法检测血清AFP。结果 PHC组GP73、AFP水平明显高于其他组(均P<0.05),GP73和AFP诊断PHC的灵敏度分别为86.36%和81.82%,GP73和AFP两者联合检测灵敏度为93.18%,与单项检测相比差异有显著性(P<0.05)。结论 GP73和AFP均可作为诊断原发性肝癌的血清标记物,二者联合检测具有更高的灵敏度,可提高诊断率。【Objective】To explore the significances of Golgi protein 73（GP73） and Alpha-fetoprotein（AFP） in the diagnosis of primary hepatic carcinoma（PHC）. 【Methods】Enzyme-linked immunosorbentassay（ELISA） and chemiluminescent immunoassay were respectively used to detect the serum level of GP73 and AFP in 44 cases of PHC, 19 cases of liver cirrhosis, 44 cases of chronic hepatitis B and 22 healthy controls. 【Results】GP73 and AFP levels were significantly higher in patients with PHC than other groups（P 0.05）. The sensitivity of GP73 and AFP for diagnosis of PHC was 86.36% and 81.82%,respectively. The sensitivity of combined examination of GP73 and AFP was 93.18%, being higher than that of single GP73 or AFP test（P 0.05）.【Conclusion】Both serum GP73 and AFP could be used as biomarkers in the diagnosis of PHC, combined detection of them could improve diagnostic accuracy, with a higher sensitivity.

关 键 词：高尔基体蛋白73 甲胎蛋白 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]