不同介入方法治疗兔VX-2肝肿瘤模型疗效的螺旋CT评价  

Therapeutic Effect of Different Interventional Methods on Hepatic Tumor of Rabbits Bearing VX-2 Tumor:An Experimental Study Evaluated with Spiral CT

作　　者：刘嵘[1] 王建华[1] 颜志平[1] 周康荣[1] 邵国良[1] 钱晟[1] 罗剑均 

机构地区：[1]上海医科大学附属中山医院放射科,上海200032

出　　处：《中国医学影像技术》2000年第11期935-937,共3页Chinese Journal of Medical Imaging Technology

基　　金："九五"国家医学科技攻关项目 !(96 90 7 0 3 0 1)

摘　　要：目的　用螺旋CT评价不同介入方法治疗兔VX 2肝肿瘤疗效。方法　 2 4只兔分为三组 ,单纯灌注化疗7只、化疗性栓塞 8只、生理盐水 9只。分别于介入术前、术后 1周、术后 2周行螺旋CT扫描 ,计算不同介入治疗后肿瘤增长率。结果　单纯灌注化疗、化疗性栓塞、生理盐水治疗后 1周肿瘤平均增长率分别为 90 88%、75 45 %、35 0 96 %。术后 2周肿瘤平均增长率分别为 2 83 49%、2 37 99%、845 43%。结论　化疗性栓塞治疗兔VX 2肝肿瘤疗效优于单纯灌注化疗 ,单纯灌注化疗优于生理盐水。螺旋CT扫描是评价兔VXPurpose To evaluate the therapeutic effectiveness of different interventional methods on the rabbits bearing VX\|2 hepatic tumor by spiral CT. Methods 24 rabbits bearing the VX\|2 hepatic tumor were divided into three groups:transcatheter artery infusion (TAI) with chemical agents ( n =7),transcatheter artery embolization (TAE) used lipiodol plus chemical agent ( n =8),0 9% physiological saline therapy ( n =9).Sprial CT scan the hepatic tumors of the rabbits was performed pre\|therapy one and two weeks after interventional therapy.The growth rate of tumors was calculated to evaluate the therapeutic effectiveness. Results The growth rate of tumors of the three groups were 90 88%,75 45%,350 96% respectively one week after interventional therapy,and the growth rate of tumors were 283 40%,237 99%,845 43% respectively two weeks after therapy. Conclusion The therapeutic effectiveness of TAE is superior to that of TAI,the therapeutic effectiveness of TAI is superior to that of physiological saline therapy.Hepatic spiral CT of rabbit bearing VX\|2 tumer is useful in the assessment of the therapeutic effect after interventional therapy. [

关 键 词：动物模型 螺旋CT 介入疗法 疗效 肝肿瘤 

分 类 号：R735.705[医药卫生—肿瘤] R730.59[医药卫生—临床医学]