尿激酶治疗多房包裹性恶性胸腔积液的疗效观察  

Observation of curative effect of urokinase in the treatment of patients with encapsulated malignant pleural effusion

作　　者：杨芳伟[1] 尤青海[2] 

机构地区：[1]利辛县人民医院呼吸内科,安徽亳州236700 [2]安徽医科大学第一附属医院呼吸科,安徽合肥230022

出　　处：《临床肺科杂志》2014年第1期79-81,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察尿激酶治疗包裹性恶性胸腔积液的临床疗效。方法收集73例肺腺癌伴包裹性恶性胸腔积液患者,随机分为两组,尿激酶组(n=37)经导管向胸腔内注入尿激酶25万U,连续3-5个周期;对照组(n=36)患者仅导管充分引流胸水。所有患者待肺完全复张后给予博莱霉素6万U胸腔注射,行胸膜固定术。比较两组患者一般特征、胸水引流量、肺复张情况和胸膜固定术成功率等;结果两组患者一般特征无显著差异,其中尿激酶组86%患者(32例)肺完全复张,对照组61%(22例)患者肺完全复张,组间差异显著(P<0.05)。两组的胸膜固定术成功率无差异(P>0.05)。结论胸腔内注射尿激酶可显著增加包裹性恶性胸腔积液患者的肺复张率,可作为恶性胸腔积液患者的常规处理方法。Objective To observer the curative effect of urokinase in the treatment of patients with encapsulated malignant pleural effusion. Methods 73 patients with malignant pleural effusion were randomly divided into two groups. The UK group( n = 370 was given 3 ~ 5 cycles of 250000U intrapleural urokinase,and the control group( n = 36) received pleural drainage only. Pleurodesis with 60000U of bleomycin was performed in all patients who had lung reexpansion after drainage. Their characteristics,pleural drainage,lung expansion assessed by chest radiography,and pleurodesis outcomes were compared between the two groups. Results Their characteristics were similar in both groups. There were 32 cases of lung reexpansion in the UK group and 22 cases in the control group( P< 0. 05). There was no significant difference in achievement rate between the two groups. Conclusion Intrapleural injection of urokinase can improve reexpansion in the treatment of patients with encapsulated malignant pleural effusion.

关 键 词：肺癌 恶性胸腔积液 胸膜固定术 尿激酶 

分 类 号：R734.2[医药卫生—肿瘤]