TTF-1和p63在肺腺癌与鳞癌的鉴别中的意义  

Differential diagnostic significance of p63 and TTF-1 between adenocarcinoma of lung and squamous cell carcinoma

作　　者：高福平[1] 魏谨[1] 马平[1] 夏莉花[1] 秦东梅[1] 

机构地区：[1]南京市高淳县人民医院病理科,江苏南京211300

出　　处：《临床肺科杂志》2014年第1期112-113,共2页Journal of Clinical Pulmonary Medicine

基　　金："南京市卫生青年人才培养工程"资助(No QRXl1344)

摘　　要：目的研究TTF-1和p63在肺腺癌及肺鳞癌中的表达及鉴别诊断中的价值。方法收集肺鳞癌69例,腺癌62例,采用免疫组织化学PV-9000法分别检测TTF-1和p63在肺腺癌及肺鳞癌中的表达情况。结果 TTF-1在肺鳞癌中未见表达(0/69),在肺腺癌中的阳性表达率为87.10%(54/62),TTF-1表达在肺鳞癌与肺腺癌中的表达差异有显著统计学意义(P<0.01);P63在肺鳞癌中的阳性表达率为97.10%(67/69),在肺腺癌中的阳性表达为4.84%(3/62),p63表达在肺鳞癌与肺腺癌中的表达差异有显著统计学意义(P<0.01)。结论根据TTF-1和p63在肺癌组织的存在特异性表达,联合检测两者有助于在肺活检标本中对肺鳞癌和肺腺癌的鉴别诊断。Objective To investigate the expression and differential diagnosis value of TrF-1 and p63 be- tween adenocarcinoma of lung and squamous cell carcinoma. Methods The study selected 69 patients with squa- mous cell carcinoma and 62 patients with adenocarcinoma of lung. The expression of TFF-1 and 1963 was detected by PV-9000. Results The positive rate of p63 was 97.10% （67/69） in patients with primary lung squamous cell carci- noma, and 4. 84% in patients with adenocarcinomas of lung （3/62）. The positive rate of TTF-1 cxpressiun was 87. 10% （54/62） in palienls with adcnocarcinonlas of hmg, and 0 in patients with lung square.us cell carciuoma. Conclusion Comhined examinatiou oTTTF-1 toni p63 is valuable in the differential diagnosis between adcuocarcinu- ma of lung and squamous cell carcinoma.

关 键 词：肺肿瘤 TTF-1 P63 免疫组织化学 鉴别诊断 

分 类 号：R734.2[医药卫生—肿瘤]