阿维菌素-β-环糊精包合物制备及工艺优化  

Peparation and optimization of technology for avermectin-β-cyclodextrin inclusion compound

作　　者：李运涛[1] 郭宁[1] 沈文[2] 

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021 [2]陕西科技大学生命科学与工程学院,陕西西安710021

出　　处：《陕西科技大学学报（自然科学版）》2014年第1期91-94,共4页Journal of Shaanxi University of Science & Technology

基　　金：陕西省科技厅科研计划项目(2011JM2005)

摘　　要：研究用β-环糊精包合阿维菌素。分别用水搅拌法、超声法和研磨法制得包合物,并采用DSC验证了包合物的生成。以高效液相色谱法测定了3种方法的包合率,对比后选择用水搅拌法包合.通过单因素实验,确定正交试验的因素水平.正交试验结果表明,最佳包合条件为主客分子投料质量比10∶1.0、包合温度35℃、包合时间8h.此条件下的包合率、收率分别为43.8%和80.4%.Avermectin was entrapped by β-cyclodextrin in this paper .Water mixing method , ultrasonic method and grinding method were used to prepare inclusion compound ,and by DSC the formation of inclusion compound was verified .Inclusion rate of the three methods was determined by high performance liquid chromatography ,and by contrast water mixing method was choosed for preparing inclusion compound .Through the single factor experi-ment ,factors and levels of orthogonal test were determined .The orthogonal experiment re-sults showed that the best conditions were temperature 35 ℃ ,the molecular mass feeding ratio 10∶1 .0 and inclusion time 8 h .Under these conditions ,the yield and the inclusion rate w ere 43 .8% and 80 .4% ,respectively .

关 键 词：阿维菌素 Β-环糊精 包合物 水搅拌法 

分 类 号：O69[理学—化学]