WIF-1基因与肺癌的诊断和治疗  

WIF-1 and the diagnose and treatment of lung cancer

作　　者：龚民[1] 王飞[1] 高志[1] 

机构地区：[1]首都医科大学附属北京友谊医院胸外科,北京100050

出　　处：《国际外科学杂志》2013年第12期835-837,共3页International Journal of Surgery

摘　　要：Wnt蛋白是一组对人体生长发育和造血等过程具有重要作用的蛋白，它们所介导的信号传导通路称为Wnt信号通路，Wnt信号通路的异常激活可引起包括肺癌在内的各种肿瘤的发生。WIF-1作为一种抑癌基因，可以抑制Wnt信号通路的异常激活，从而避免肺癌的发生。而WIF-1一旦发生启动子甲基化，便会引起WIF-1表达下调，进而激活Wnt信号通路，导致肺癌的发生。因此，检测WIF-1的甲基化可以有助于肺癌的临床诊断，针对WIF-1甲基化的治疗也可作为肺癌的治疗方法之一。Wingless type protein （ Wnt protein） is a group of protein which plays an important role in the process of animal growth and hemopoiesis, the signaling pathway they conducted was called Wnt signaling pathway, and its abnormal activation can lead to many tumors,include lung caner. As a tumor suppressor gene, WIF-1 can restrain the activation of Wnt signaling pathway, which can avoid lung cancer. WIF- 1 ＇ s methylation can downregulate the expression of WIF- 1, which can activate Wnt signaling pathway and cause lung cancer. So the detection of WIF- 1 ＇s methylation may contribute to clinical diagnose of lung cancer, and therapy of WIF- 1＇s methylation may be one of the treatment metheds of lung cancer.

关 键 词：WIF-1基因 WNT蛋白质类 肺肿瘤 小细胞肺癌 诊断 治疗学 

分 类 号：R734.2[医药卫生—肿瘤]