靶向肿瘤细胞自噬通路的植物天然产物研究进展  

Plant natural compounds targeted cancer cell autophagy:research advances

作　　者：刘捷[1] 欧阳亮[1] 陈亿[1] 刘博[1] 

机构地区：[1]四川大学华西医院生物治疗国家重点实验室,成都610041

出　　处：《国际药学研究杂志》2013年第6期688-694,共7页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81260628;81202403)

摘　　要：从植物中提取的天然化合物是肿瘤治疗药物的一个宝贵来源。通过天然产物靶向肿瘤细胞自噬通路的研究可以合理地开发利用天然产物资源进行恶性肿瘤的预防和治疗。本文总结了一些具有代表性的植物天然产物(如姜黄素、白藜芦醇、紫杉醇、冬凌草甲素和槲皮素等),及其通过靶向细胞内自噬通路导致的肿瘤细胞死亡机制涉及经典通路如Ras-Raf、Beclin-1、PI3KCⅠ/Akt/mTOR、FOXO1和p53等。以期为抗肿瘤药物的研发提供新的思路。Extracted from plants, natural compounds are valuable resources to treat cancer. The study of natural compounds which can induce autophagic cancer cell death can lead to effective prevention and therapy for cancers. In our review, we summarize several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridoniu, quercetin and how they target auto- phagy to lead to cancer cell death. By several related experiments, we conclude some core autophagic pathways, involved in Ras-Raf signaling, Beelin-1 interactome, PI3KC I/Akt/mTOR, FOXO1 signaling and p53. These compounds may shed new light on the re- search of anti-tumor drugs in the future.

关 键 词：植物天然产物 姜黄素 白藜芦醇 自噬 肿瘤细胞 信号转导 

分 类 号：R285[医药卫生—中药学]