胰腺原发性腺鳞癌9例临床病理分析及文献回顾  

Clinicopathologic analysis of pancreatic adenosquamous carcinoma:a report of 9 cases and literature review

作　　者：朱珍[1] 郑建明[1] 

机构地区：[1]上海第二军医大学附属长海医院病理科,200433

出　　处：《国际消化病杂志》2013年第6期411-414,共4页International Journal of Digestive Diseases

摘　　要：目的分析胰腺原发性腺鳞癌的临床和病理学特点，以提高对该病的认识和诊治水平。方法对2012年11月至2013年3月本院收治的9例胰腺原发性腺鳞癌患者的临床病理学资料进行回顾性分析，同时对14篇有关腺鳞癌的文献报道进行复习。结果在9例胰腺原发性腺鳞癌中，肿瘤位于胰头部者3例，胰体尾部5例，胰颈体1例。肿瘤的平均直径为（4．17±1．52）cm；其中1例侵犯门静脉，1例侵犯胃窦黏膜，1例侵犯十二指肠，1例侵犯横结肠，1例侵犯左侧肾上腺包膜，4例伴有胰周淋巴结转移；获随访的8例中死亡1例，术后生存时间为1～5个月，平均3．0个月。结论胰腺原发性腺鳞癌是一种少见的胰腺恶性肿瘤，组织学上肿瘤由导管腺癌成分和鳞状细胞癌成分混合构成，其临床表现与胰腺导管腺癌相似。通过早期诊断与手术结合放射、化学治疗可提高疗效。Objective To analyze the clinical and pathological features of adenosquamous carcinoma of the pancreas, and improve the understanding and diagnosis of the disease. Methods Nine cases of adenosquamous carcinoma of pancreas admitted between Nov 2012 and Mar 2013 in Changhai Hospital and 14 documents were analyzed retrospectively. Results Of the 9 patients, 3 had tumor located in the pancreatic head, 5 in the body and tail, and 1 in the neck and body. The mean diameter of the tumor was 4.17 ± 1.52 cm, of which 1 had portal vein invasion, 1 with infiltration of the gastric antrum, 1 with infiltration of the duodenum and 1 with infiltration of the capsule of left adrenal gland envelope, and 4 with lymph node metastasis. Of the 8 patients which were followed-up, 1 died with a mean postoperative survival time of 3.0 months （1 - 5 months）. Conclusions Pancreatic adenosquamous carcinoma is a rare entity of pancreatic tumor with symptoms similar to pancreatic ductal carcinoma. Early diagnosis and treatment could contribute to improving the outcome.

关 键 词：胰腺肿瘤 腺鳞癌 诊断 文献回顾 

分 类 号：R735.9[医药卫生—肿瘤]