肿瘤射频消融治疗后的免疫反应及抗肿瘤效应  

Immune responses and anti-tumor effects after radiofrequency ablation therapy in tumor patients

作　　者：蔡凯[1] 张闯[1] 江涛[2] 

机构地区：[1]解放军第81医院肿瘤生物治疗科,南京210002 [2]解放军第81医院肿瘤外科,南京210002

出　　处：《国际肿瘤学杂志》2013年第11期826-829,共4页Journal of International Oncology

摘　　要：射频消融治疗不仅造成局部肿瘤细胞的坏死，产生免疫原性的肿瘤相关抗原，还可产生大量炎性细胞因子和多种免疫原性介质，促进免疫细胞的局部浸润和活化，刺激免疫系统产生一定的抗肿瘤效应，但是这种抗肿瘤作用的强度较弱，不足以抵抗肿瘤生长。将射频消融治疗联合特定的免疫治疗如免疫刺激剂、过继免疫细胞治疗、树突状细胞疫苗、单克隆抗体等，可以取得最大临床获益，是免疫治疗有机融人肿瘤综合治疗的一个很好的模式。Radiofrequency ablation therapy not only causes the necrosis of localized tumor cells, but also produces immunogenic tumor associated antigens and a large number of inflammatory cytokines and a varie- ty of immunogenic mediums, which promotes the local infiltration and activation of immune ceils and stimulates the immune system to produce certain anti-tumor effect, But the intensity of anti-tumor effect is feeble and is insufficient to inhibit the growth of tumor cells. Radiofrequency ablation therapy combined with special immuno- therapies, such as immune stimulants, adoptive immunity ceils therapy, dendritic cell vaccines, monoclonal antibodies and so on, can maximize the clinical benefit, which is a good pattern about tumor comprehensive treatment containing immunotherapy.

关 键 词：肿瘤 免疫系统 细胞因子类 淋巴细胞 射频消融 

分 类 号：R730.5[医药卫生—肿瘤]