肝硬化PLT计数与AST/ALT比值的关联性  

Relationship Between PLT Counting and AST/ALT Ratio of Hepatic Cirrhosis

作　　者：胡宏章[1] 张焕强[1] 唐虹[1] 王军荐 姜桂容 车辉娟[1] 严薛丹[1] 

机构地区：[1]四川大学华西医院实验医学科,成都610041

出　　处：《成都医学院学报》2013年第6期637-639,共3页Journal of Chengdu Medical College

基　　金：国家自然科学基金资助项目(NO:81101326)

摘　　要：目的探讨肝硬化PLT计数与AST/ALT比值的关系。方法分析96例肝硬化患者PLT计数与AST/ALT比值的相关性,应用Fisher逐步判别分析比较单独及联合应用二者对患者预后预测的准确性。同时应用受试者工作特性曲线(receiver operating characteristic curve,ROC)对其在肝硬化中的应用价值进行评价。结果 PLT计数与AST/ALT比值呈显著负相关(r=-0.86,P<0.01),ROC曲线下1/PLT与AST/ALT的面积分别为0.78、0.81,ROC曲线下面积差异无统计学意义(Z=5.23,P=0.47);PLT计数与AST/ALT比值对预后预测的敏感性、特异性、准确率分别为61.1%、67.6%、71.9%;63.1%、69.8%、72.8%,联合应用二者后其特异性和准确率可分别提高至75.8%、79.8%。结论 PLT计数与AST/ALT比值存在密切相关,联合应用二者对于准确判断病情、估计预后有参考价值。Objective To investigate the relationship between PLT counting and AST/ALT ratio of hepatic cirrhosis. Methods The relationship between PLT counting and AST/ALT ratio of 96 patients with hepatic cirrhosis was investigated, using Fisher stepwise discriminant analysis to compare the accuracy of prognosis judgement in separate and combined application of the two parameters. The receiver operating characteristic curve （ROC）was used to appraise the value of them in patients with cirrhosis. Results Significant inverse correlation were found between PLT counting and AST/ALT ratio（r=-0.86, P%0.01）, the areas of 1/PLT and AST/ALT under ROC curve were 0.78 and 0.81, there were statistically differences in terms of the areas under ROC curve（Z= 5.23, P=0.47） ;according to PLT counting and AST/ALT ratio, the sensitivity, specificity and accuracy was 61. 1%, 67.6% ,71. 9% for PLT counting and 63. 1%, 69. 8%, 72. 8% for AST/ALT, respectively. The specificity and accuracy of the two combined application can be increased to 75.8% and 79.8% respectively. Conclusion The PLT counting and AST/ALT ratio is closely related, the combined application of the two has reference value for estimating the disease accurately and judging the prognosis.

关 键 词：肝硬化患者 PLT计数 AST ALT比值 ROC曲线 

分 类 号：R575.2[医药卫生—消化系统]