口腔鳞癌癌旁上皮中细胞凋亡与细胞增殖的关系  

The Relationship Between Apoptosis and Proliferation in Epithelium Adjacent to Oral Squamous Cell Carcinoma

作　　者：葛培岩[1] 王国平[2] 田明铭 钟滨[1] 俞翔耀[2] 

机构地区：[1]同济大学口腔医学院,上海200072 [2]同济大学铁路医院,200072 [3]同济大学甘泉医院,200065

出　　处：《口腔医学》2000年第4期169-171,共3页Stomatology

基　　金：铁道部科技基金资助课题 !(J97Z0 15 )

摘　　要：目的 :探讨口腔鳞癌癌旁上皮中细胞凋亡与细胞增殖的病理意义及其相互关系。方法 :利用脱氧核糖核酸末端转移酶介导的dUTP缺口末端标记 (TUNEL)技术、增殖细胞核抗原 (PCNA)免疫组织化学染色对 30例口腔鳞癌标本癌旁上皮等4个不同区域中凋亡细胞及增殖细胞的分布和密度进行观察和比较。结果 :与正常区域相比较 ,癌旁上皮中凋亡细胞及增殖细胞分布异常且细胞密度增高 ;肿瘤组织中 ,凋亡细胞明显减少 ,增殖细胞明显增多。结论 :口腔鳞癌癌旁上皮中存在活跃的细胞凋亡及细胞增殖 。Objective:To study the Significance and relationship between apoptosis and proliferation in the pathologic changes of epithelium adjacent to oral squamous cell carcinoma.Methods:Using terminal deoxynucleotidyl transferase-mediated dUTP niok end labeling (TUNEL) technique and PCNA immunohistochemical staining,the distribution and density of apoptosis cells and proliferating cells in four different regions of thirty specimens were observed.Results:The distributions of apoptotic cells and proliferating cells were abnormal and their densities significantly increased in epithelium adjacent to carcinoma compared with normal regions;Tumor areas showed that apoptotic cells decreased and proliferating cells increased significantly.Conclusion:The epithelium adjacent oral squamous cell carcinoma have highly apoptotic and proliferating ability and play an important role in malignant tansformation.

关 键 词：口腔鳞癌 癌旁上皮 细胞凋亡 细胞增殖 

分 类 号：R739.85[医药卫生—肿瘤]