人乳头瘤病毒、疱疹病毒I型及人巨细胞病毒与口腔鳞癌关系的研究  

A Study on the Association Among the Infections of Human Papillomavirus、Herpes Simplex Virus Type Ⅰ、Human Cytomegalivirus and Oral Sqramous Cell Carcinoma

作　　者：侯炜[1] 杨占秋[1] 龙星[2] 申元英[3] 曲虹 

机构地区：[1]湖北医科大学病毒所,430071 [2]湖北医科大学口腔医学院外科 [3]云南大理医学院微生物教研室 [4]同济医科大学微生物教研室

出　　处：《口腔医学》2000年第4期180-181,共2页Stomatology

摘　　要：目的 :研究口腔鳞癌与人乳头瘤病毒 (HPV)、疱疹病毒I型 (HSV -I)和人巨细胞病毒 (HCMV)的关系。方法 :采用斑点杂交和PCR技术检测 32例口腔鳞癌、14例口腔白斑和 10例正常口腔粘膜中HPV1 6 、HSV -I及HCMVDNA。结果 :在正常口腔粘膜、白斑及口腔鳞癌中HPV1 6 、HSV -I及HCMVDNA感染率分别为 0 %、35 7%、5 0 0 % ,40 0 %、5 0 0 %、43 3%和 0 %、14 3%、2 8 1% ,口腔鳞癌及白斑组织中HPV1 6 -DNA的检出率均高于正常口腔 ,且差别具有显著性 (p <0 0 5 ) ;但HSV -I和HCMVDNA在口腔疾患中的检出率与正常比较无显著差别 (p >0 0 5 )。结论 :HPV1 6 感染与口腔鳞癌的发生相关 ;HSV -I和HCMV可能参予口腔鳞癌的发生及发展 ,并且与HPV1 6Objective:To demonstrate the presence of human papillomavirus(HPV) herpes simplex virus type I(HSV I)、human cytomegalovirus(HCMV)in oral spuamous cell carcinoma(OSCC).Methods:HPV 16 、HSV I and HCMVNDA sequence in normal oral tissue、leukoplakia and OSCC by dot hybridization and polymerase chain reaction were detected.[WT5”FZ]Results:It was showed that the positive rates of HPV 16 DNA in OSCC and leukoplakoa were significanly higher than that in normal oral tissue([WT5”BX]p<0 05) However there was no significance in the positive rates of HSV I and HCMVDNA between oral diseases and normal oral tissue(p>0.05).Conclusion:The results indicate that infection of HPV 16 may be related to the occurrence of OSCC;HSV I and HCMV may play an important role in the development of OSCC and probably enhance the oncogensis of HPV 16

关 键 词：口腔鳞癌 人乳头瘤病病毒 疱诊病毒I型 HCMV 

分 类 号：R739.802[医药卫生—肿瘤]