观察内镜下5-Fu缓释化疗粒子注射治疗晚期消化道肿瘤的临床疗效  

Clinical efficacy of endoscopic 5-Fu slow-release particles on advance gastrointestinal cancer

作　　者：孙曙辉 龚明辉[1] 查涛[1] 

机构地区：[1]安徽省怀远县第二人民医院消化内科,233400

出　　处：《中国实用医刊》2014年第2期63-65,共3页Chinese Journal of Practical Medicine

摘　　要：目的初步评价化疗缓释粒子植入治疗晚期消化道肿瘤的临床效果及不良反应。方法选取15例消化道晚期肿瘤患者，内镜直视下对胃、肠道肿瘤结节及浸润处行多点或密集型植入粒子，45～60粒，5-Fu缓释粒子平均注射0．15g，比较治疗前后患者的肝、肾功能状况。结果15例患者施行粒子植入治疗后完全缓解2例，部分缓解5例，稳定6例，进展2例，有效率为80％。1个月后内镜复查可见病灶部位均呈现不同程度的病变局限、平坦、腔径增宽，且所有患者均未发生出血、穿孔等并发症，治疗前后肝、肾功能检查未见明显差异。结论内镜下植入化疗缓释药物5-Fu治疗晚期消化道肿瘤是一种新型的治疗手段，能够有效改善患者症状，提高肿瘤局部控制率，无肝、肾功能损害等不良反应，为一种不良反应小、耐受性好的站息治疗方法。Objective To evaluate the clinical effect and adverse reactions of endoscopic implantation of slow-release particles for the treatment of advanced gastrointestinal cancer. Methods Fifteen patients with advanced gastrointestinal tumor were chose. During the endoscopic procedure, slow-releasing were implanted densely into the tumors and infiltrated area, 45 - 60 pieces of agents were injected, which containing an average dose of 100 mg 5-Fu. Liver and kidney function of patients were compared bewas complete remission, 5 cases were partial remission, 6 cases were in stable and 2 cases were in pro- gress. The effective rate was 80%. The endoscopy examination showed that the size of tumors reduced in various degrees at one month after the implantation. No hemorrhage or perforation was observed. Liver and kidney function were stable after implantation. Conclusions Endoscopic implantation of sustainedrelease chemotherateutic drug 5-Fu in treatment of advanced gastrointestinal cancer is a new means of treatment, which can improve symptoms and local tumor control rate of patients, there were no liver and kidney function damage or other adverse reactions. The method has little poisonous side effect and is a well-tolerated palliative treatment.

关 键 词：消化道肿瘤 氟尿嘧啶缓释化疗粒子 内镜植入 

分 类 号：R735[医药卫生—肿瘤]