幽门螺杆菌VacA基因型与胃溃疡兰索拉唑三联疗法疗效的关系  

Relationship between lansoprasol triple therapy effect and alleles of vacuolating cytotoxin genotype in patients with gastric ulcer

作　　者：牛省利 杨帆[2] 

机构地区：[1]河南省平顶山市第一人民医院消化科,467000 [2]河南省医学会

出　　处：《中国实用医刊》2014年第2期66-68,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨幽门螺杆菌VacA基因型与胃溃疡兰索拉唑三联疗法疗效的关系。方法选择2010年1月至2012年1月在平顶山市第一人民医院消化科门诊及住院治疗的胃溃疡患者150例，采用兰索拉唑、阿莫西林、克拉霉素三联标准抗幽门螺杆菌治疗。菌株分离培养后用PCR方法检测VacA基因亚型。结果150例患者中144例完成治疗，6例失访。130例（90．2％）患者根除幽门螺杆菌。未根治组m1型患者的比例（78．6％）高于根治组（28．4％），且差异有统计学意义（P〈0．01）。结论幽门螺杆菌VacAm区基因型与胃溃疡患者兰索拉唑三联疗法疗效有关，对治疗结局具有一定的预测作用。Objective To investigate the relationship between lansoprasol triple therapy effect and alleles of vacuolating acytotoxin （VacA） genotype in patients with gastric ulcer. Methods From Jan. 2010 to Jan. 2012, 150 patients with gastric ulcer were enrolled. All the patients were treated with clarithromycin, amoxicillin and lansoprasol. Helicobacter pylori was isolated and cultured. PCR was used to detect the Helicobacter pylori strains VacA gene subtypes. Results Helicobacter pylori was eradicated in 130 cases （90. 2% ） of the 144 patients who had completed the treatment. The bacteria from 144 patients were genotyped. The significant disease-associated difference in patterns was observed. VacA ml allele was represented more disproportionately among patients with eradication failures （78.6%） than that in those with successful eradication（28. 4% ）（P 〈 0. 01 ）. Conclusions The genotypes of vacA mid region alleles can influence the anti-helicobacter pylori efficiency and has certain predicative value on triple therapy effect.

关 键 词：幽门螺杆菌 VACA基因 胃溃疡 兰索拉唑 

分 类 号：R573.1[医药卫生—消化系统]