卵巢浆液性肿瘤血管生成与rasp21表达及临床预后  

Study of angiogensis of ovarian serous neoplasms and ras p21 expression as well as their clinical prognosis

作　　者：廖予妹[1] 耿正惠[1] 王嘉莉[2] 魏丽惠[3] 

机构地区：[1]河南医科大学附属第二医院,郑州450003 [2]河南省肿瘤医院,郑州45000 [3]北京医科大学人民医院

出　　处：《中国综合临床》2000年第12期937-938,共2页Clinical Medicine of China

摘　　要：目的　探讨血管生成卵巢浆液性肿瘤 ras p2 1表达及预后的关系。方法　应用免疫组化 LSAB法 ,以 CD34单克隆抗体标记血管内皮细胞对 10例卵巢浆液性囊腺瘤 (囊腺瘤 )及 5 0例卵巢浆液性囊腺癌组织微血管密度 (MVD,微血管数 /2 0 0× )进行了观察。同时 ,检测肿瘤组织中 ras基因产物 p2 1蛋白的表达情况 ,并结合临床资料进行分析。结果　卵巢癌的 MVD显著高于囊腺瘤 (P<0 .0 5 ) ,ras p2 1过度表达组卵巢癌 MVD显著高于 ras p2 1非过度表达及阴性表达组 (P均 <0 .0 1)。病理分级 级及 级癌的 MVD均显著高于病理分级 级癌 (均 P<0 .0 1)。 Kaplan-Meier分析 MVD高密度组的生存率明显低于低密度组 (P<0 .0 1)。结论　卵巢浆液性肿瘤的血管生成与肿瘤细胞本身的生物学特性有关 ,肿瘤血管生成分析可以作为临床判断卵巢浆液性癌预后的指标之一。Objective To study the relationship between tumor angiogenesis and expression of ras p21 protein as well as the prognosis in serous ovarian neoplasms.Methods Microvessel density (MCD) and expression of ras p21 protein in issues of 10 adenomas and 50 serous ovarian cancers were observed by immunohistochemical staining methods with monoclonal antibody CD 34 to mark vascular endotheliocytes.Results Microvessel density in specimens from over expression of ras p21 protein and from grade Ⅱ and Ⅲ was significantly higher than that in specimens from low expression or negative expression of ras p21 protein as well as from grade I (P<0.01).Microvessel density was associated with overall survival by Kaplan Meier analysis.Conclusion Neocascularization of serous ovarian neoplasms is associated with differentiation of neoplasms,a significant relationship between microvesssel density and prognosis.Moreover,the analysis of neovascularization may be an useful prognostic factor in serous ovarian cancer.

关 键 词：卵巢肿瘤 浆液性肿瘤 血管生成 RAS基因 预后 

分 类 号：R737.31[医药卫生—肿瘤]