NDRG1基因在子宫内膜癌组织中的表达及其临床意义  

Expression of NDRG1 in endometrial carcinoma and its clinical significance

作　　者：潘景媛 耿晓星[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2013年第3期240-242,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅项目(12511343)

摘　　要：目的探讨分化相关基因NDRG1蛋白在子宫内膜癌中的表达及临床意义。方法采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶链接法检测子宫内膜癌组、不典型增生子宫内膜组及正常子宫内膜组中NDRG1蛋白的表达。结果子宫内膜癌组中NDRG1表达水平明显高于不典型增生子宫内膜组及正常子宫内膜组,表达水平与肌层浸润、淋巴结转移有关,深肌层浸润的表达高于浅肌层浸润,有淋巴结转移的表达高于无淋巴结转移,NDRG1蛋白表达与癌组织的分级、FIGO临床分期无关。结论NDRG1蛋白的高表达与子宫内膜癌的发生发展有关;检测NDRG1蛋白对于子宫内膜癌的早期诊断有重要参考价值。Objective To explore the expression of N-myc downstream regulated gene 1 （NDRG1） in endometrial carcinoma （EC） was and their relationship.Methods The expression of NDRG1 was detected by immunohistochemical methods in EC tissues （with lymph node metastasis,without lymphnode metastasis）,the cases of mucosa adjacent to cancer,and the normal tissues.Results The expression of NDRG1 in cancer tissues was higher than those of mucosa adjacent to cancer and normnal endometriam.There was significant difference in NDRG1 expression between EC with different differentiation and between the cases with or without lymph node metastasis.Conclusion NDRG1 protein may be related to oncogenesis of EC,and has clinic value for early diagnosis of EC.

关 键 词：NDRG1 子宫内膜癌 基因表达 

分 类 号：R737.33[医药卫生—肿瘤]