利培酮对精神分裂症患者甲状腺激素、细胞间黏附因子-1的影响  

Effects of risperidone on thyroid hormone and sICAM-1 in patients with schizophrenia

作　　者：李宝琴[1] 秦青[1] 赵景[1] 任会鹏[1] 王立芹[1] 王洪智[2] 

机构地区：[1]河北医科大学第一医院检验科,河北石家庄050031 [2]哈尔滨医科大学附属第一医院护理支持中心,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2013年第3期250-253,共4页Journal of Harbin Medical University

基　　金：河北省科技厅支撑计划指令性课题(11276103D-44)

摘　　要：目的探讨利培酮对精神分裂症患者甲状腺激素、可溶性细胞间黏附分子-1(sICAM-1)的变化及疗效观察。方法选择首发精神分裂症患者50例,服用利培酮治疗前及8周后分别检测甲状腺激素、sICAM-1水平。治疗前后进行PANSS量表评分,比较甲状腺激素及sICAM-1的水平与PANSS评分的相关性。结果患者经利培酮治疗后,FT3、T4有明显差异(P<0.05),sICAM-1有非常明显的差异(P<0.001)。PANSS评分治疗前后有明显差异(P<0.05),PANSS各评分与甲状腺激素水平间没有相关性,与sICAM-1水平间呈正相关。结论长期服用利培酮的精神分裂症患者要监测其甲状腺激素水平及sICAM-1水平,以便于临床医生调整用药和选择合理有效的治疗方案。Objective To investigate the changes and effects of risperidone on thyroid hormone and sICAM-1 in patients with schizophrenia.Methods Fifty patients with first-episode schizophrenia were selected,whose thyroid hormone levels and sICAM-1 were detected before and 8 weeks after taking risperidone.PANSS score was assessed before and after treatment,then correlation between thyroid hormone and sICAM-1 levels and PANSS score was studied.Results FT3,T4 had significant differences in patients treated with risperidone （P ＜ 0.05）,and sICAM-1 had a very significant difference （P ＜0.001）.PANSS score was significantly different before and after treatment （P ＜ 0.05）.There was no correlation between the PANSS score and the level of thyroid hormone,but the sICAM-1 level was positively correlated with PANSS score.Conclusion Long-term use of risperidone in patients with schizophrenia should to be monitor the levels of thyroid hormone and sICAM-1,that facilitate the clinicians effectively adjust and reasonably choose the medication treatment scheme.

关 键 词：精神分裂症 利培酮 甲状腺激素 可溶性细胞间黏附分子-1 

分 类 号：R749.3[医药卫生—神经病学与精神病学]