galectin-1与galectin-3在黑色素细胞病变中的表达及预后意义  

Expression and prognostic significance of galectin-1 and galectin-3 in benign nevi and melanomas

作　　者：李忠武[1] 王燕[1] 薛卫成[1] 斯璐[2] 崔传亮[2] 曹登峰[1] 周立新[1] 郭军[2] 陆爱萍[1] 

机构地区：[1]100142北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室病理科 [2]100142北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室肾癌黑色素瘤科

出　　处：《中华病理学杂志》2013年第12期801-805,共5页Chinese Journal of Pathology

基　　金：北京科技新星计划项目（2010B033）;北京市卫生系统高层次卫生技术人才培养计划（2011-03-088）

摘　　要：目的 探讨galectin-1和galectin-3在不同黑色素细胞病变中的表达及其临床预后意义.方法 应用组织芯片及免疫组织化学EnVision法检测galectin-1和galectin-3在39例良性皮肤痣、58例皮肤原发恶性黑色素瘤、24例黏膜原发恶性黑色素瘤、77例转移性黑色素瘤中的表达.结果 galeetin-1和galeetin-3在良性皮肤痣中的表达均高于皮肤原发恶性黑色素瘤、黏膜原发恶性黑色素瘤及转移性黑色素瘤（均P＜0.01）.galectin-3在皮肤原发恶性黑色素瘤胞核中的表达高于黏膜原发恶性黑色素瘤（P＜0.01）及转移性黑色素瘤（P＜0.01）,并与患者年龄、肿瘤组织坏死状态相关（P＜0.05）;生存及预后分析显示,Clark分级与皮肤原发恶性黑色素瘤患者总生存时间相关（P=0.037）.galectin-3在所有黑色素瘤病例瘤细胞核内的表达水平与TNM分期是影响患者总生存时间的相关因素（P＜0.01）,但只有TNM分期是独立预后因素.结论 galectin-1和galectin-3在黑色素瘤中表达下降;galectin-3在胞核内的表达下降,可能预示黑色素瘤预后不良.Objective To study the expression and prognostic significance of galectin-1 and galectin-3 in different melanocytic lesions.Methods The expression of galectin-1 and galectin-3 in 39 cases of benign nevus,58 cases of primary cutaneous melanoma,24 cases of primary mucosal melanoma,69 cases of melanoma with lymph node metastasis and 8 cases of melanoma with distant metastasis were studied by immunohistochemistry and tissue microarray.Results The expression of galectin-1 and galectin-3 was higher in benign nevi than in melanomas （P 〈 0.01）.The nuclear expression of galectin-3 was higher in primary cutaneous melanomas than in primary mucosal melanomas or melanomas with metastases （P 〈 0.01,respectively）.The expression correlated with age of patients （P 〈0.05）,necrosis （P 〈0.05） and survival time （P 〈0.01）.Clark＇s level also correlated with survival time in patients with cutaneous melanomas （P =0.037）.TNM staging was the only independent prognostic factor for melanomas （P 〈 0.01）.Conclusions The expression of galectin-1 and galectin-3 is decreased in melanomas.The decrease in nuclear expression of galectin-3 may represent a poor prognostic factor for melanomas.TNM staging is an independent prognostic factor which influences the survival time.

关 键 词：黑色素瘤 免疫组织化学 预后 

分 类 号：R739.5[医药卫生—肿瘤]