CT灌注参数对食管癌放疗疗效评价的研究  

CT perfusion in the evaluation of the effects of radiation therapy in esophageal carcinoma

作　　者：袁刚[1] 周胜利[1] 王江涛[1] 许新堂[1] 

机构地区：[1]江苏省连云港市第一人民医院影像科,江苏连云港222002

出　　处：《医学影像学杂志》2013年第12期1944-1947,共4页Journal of Medical Imaging

摘　　要：目的通过对食管癌放疗前后CT灌注参数的比较,得出一种无创评价肿瘤疗效的可靠方法,为临床正确治疗方案的确定、疗效的判定及预后评估提供依据。方法对经过病理证实的20例食管癌放疗患者,于放疗前1周及放疗后1周内行CT灌注,绘制ROI的TDC,并计算BF、BV、MTT、PS数值,随访确定有效组及无效组,分别比较有效组、无效组放疗前、后CT灌注参数差异有无统计学意义,并比较有效组与无效组放疗前CT灌注参数差异有无统计学意义。结果食管癌放疗有效组放疗前后BF、BV、MTT差异有统计学意义(P<0.05),P值分别为0.000、0.022、0.005,PS差异无统计学意义(P>0.05);食管癌放疗无效组放疗前后BF、BV、MTT、PS差异均无统计学意义(P>0.05);有效组与无效组放疗前BF、MTT差异有统计学意义(P<0.05),P值分别为0.027、0.047,BV、PS差异无统计学意义(P>0.05)。结论 CT灌注参数对评价食管癌放疗疗效有一定的价值,对拥有高BF、低MTT数值的患者容易获得更好的放疗疗效,为正确治疗方案的确定、疗效的判定及预后评估提供依据。Objective Comparison study of CT perfusion was started for pre- and post radiotherapy of esophageal cell carcinoma. A reliable method of the evaluation of the effects of radiation therapy in esophageal carcinoma was obtained, and it could provide evidence for the optimization of a reasonable treatment protocol, the determinant of curative effect and the evaluation of the patient＇s prognosis. Methods Twenty patients with histologically diagnosed esophageal carcinoma underwent CT perfusion examinations one week before and one week after radiotherapy. The TDC of the ROI was drawn, and the data of BF, BV, MTT and PS were calculated. The effective group and invalid group were confirmed by follow-up visit. Statistical analyses were performed to respectively compare CT perfusion parameters between pre- and post-radio therapy of effective group and invalid group of esophageal carcinoma. Statistical analyses were performed to compare CT perfusion parameters of pre-radiotherapy between effective group and invalid group. Results The response rate （RR） was eighty percent. There were significant differences in BF, BV and MTT between pre-and post-radiotherapy of effective group of esophageal cell carcinoma （ P=0. 000, P =0. 022, P=0. 005, P %0.05）, and there was no significant differ ence in PS（ P 〉0.05） ; There were no significant differences in BF, BV, MTT and PS between pre-and post-radiotherapy of invalid group （ P 〉 0.05）; There were significant differences in BF and MTT before radiotherapy between effective group and invalid group （ P 0. 027, P = 0. 047, P %0.05）, and there were no significant differences in BV and PS（ P〉 0.05）. Conclusion There is a certain meaning in assessing the efficacy of radiotherapy of CT perfusion parameters. The patients who have high BF and low MTT are easy to get a better efficacy of radiotherapy, and it can provide evidence for the optimization of a reasonable treatment protocol, the determinant of curative effect and the evaluation of the patient＇s prognosi

关 键 词：食管癌 体层摄影技术 X线计算机 灌注成像 放疗 

分 类 号：R735.1[医药卫生—肿瘤] R814.42[医药卫生—临床医学]